Proposal Peer Review Paper

Proposal Peer Review Paper

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Proposal Peer Review Rubric Criteria Abstract Is the abstract ~150 words or less? As the reader, summarize the purpose of the document & the change that you obtained from the abstracts. Is the justification for the change appropriate? Specify your view on the the change. Introduction/Background – Is the system and the proposed changes clearly defined? Specify any improvements would you make. – Is the background focused on only giving the information necessary? Specify any additional aspects you think should be included or removed. Audience/Tone Based on your reading, what is the tone of the proposal? What changes do you recommend to ensure a professional tone written to the appropriate audience? Body of Proposal – Is the problem with the current system clearly defined & justified? What improvements should be made. – Are the proposed changes clearly defined and well motivated by the problem statement? Specify improvements which can be made. – Do you believe it is plausible that the proposed changes could solve most, if not all, of the problem statement? i.e. was the problem statement concise and exact? Any suggestions? – Is it the market size for this system clearly outlined? Are statistics reported from credible market sources(Gartner, Forrester, IBIS World)? Provide Market Journal Database Link Comments Criteria Benefits/Cost/Schedule/etc – Are the benefits both desirable and convincing to the audience of this proposal? – Are the benefits of the proposed changes backed up by some amount of research, where necessary? – Are the costs and schedule plausible, given the writer’s background? (i.e. was any effort put into coming up with good figures?) Are there sufficient details specific to the project included in the schedule (ie. not a copy/paste Agile or waterfall schedule)? – Are the members of the team listed with appropriate qualifications? Does their professional background and level of skill meet the scope of the technical work outlined in the schedule? Overall Feedback Your overall critique of the review Comments PROPOSAL: AI-Driven Booking Ecosystem PREPARED FOR Matt Goldberg TripAdvisor PREPARED BY Fatih Sen November 5, 2023 1 AI-Driven Booking Ecosystem Proposal Abstract TripAdvisor is in the perfect position to fill in all the gaps in the current online travel market. For TripAdvisor evolving into a holistic AI-driven booking ecosystem that seamlessly integrates personalized trip plans and suggestions, is recognizing the platform’s present limits in responding to customer preferences and the absence of uniform booking capabilities. This solution suggests a paradigm change. TripAdvisor can improve user happiness, engagement, and loyalty by employing AI for personalized travel planning and implementing a one-stop booking platform. The theoretical underpinning, advantages, and practicality of integrating AI elements are highlighted in the technical part. According to research findings, AI-assessed data has the potential to improve income. The market size section makes clear the insights of the travel sector, which is expected to increase significantly. The suggested methodology details a staged implementation strategy, with the management portion outlining the expert team and budget, assuring a successful implementation. 2 AI-Driven Booking Ecosystem Proposal Table of Contents ABSTRACT…………………………………………………………………………………….. 2 INTRODUCTION……………………………………………………………………………… 4 System Overview………………………………………………………………………. 4 Problem……………………………………………………………………………………. 4 Solution……………………………………………………………………………………. 5 THEORETICAL SECTION………………………………………………………………… 5 Theory……………………………………………………………………………………….5 Benefits……………………………………………………………………………………..6 Feasibility…………………………………………………………………………………. 9 Market Size……………………………………………………………………………….. 9 Methodology…………………………………………………………………………… 10 MANAGEMENT SECTION………………………………………………………………. 11 Team and Budget…………………………………………………………………….. 11 Schedule…………………………………………………………………………………. 11 CONCLUSION………………………………………………………………………………..12 Works Cited………………………………………………………………………………….. 13 3 AI-Driven Booking Ecosystem Proposal Introduction System Overview TripAdvisor is a well-known and trusted online and mobile travel platform that provides travelers with information, reviews, and recommendations on all aspects of travel. From hotels, restaurants, attractions, and more. To effectively plan their trips, users can browse a large database of both official and user-generated content, browse photos, and read detailed reviews. Aside from its review-centric features, this user-driven platform has become a go-to destination for travelers worldwide, providing valuable insights and guidance for a wide range of travel experiences, making it an indispensable tool for both leisure and business travelers. Problem TripAdvisor though comprehensive in its methodology and approach towards displaying a breadth of activities and locations across the world for its users to choose from, doesn’t approach users by catering to them with personalized itineraries and travel packages based on their experiences. On top of this, it also lacks the ability for its users to take the next steps into unifying and booking all their travel decisions on the platform itself. 4 AI-Driven Booking Ecosystem Proposal Solution TripAdvisor’s evolution into a comprehensive one-stop platform for booking flights, accommodations, activities, and transportation, seamlessly integrated with AI-driven personalized travel itineraries and recommendations tailored to each user’s preferences and past booking experiences, can cover all of the gaps that can currently be closed on the platform in terms of increasing user engagement, loyalty, and revenue potential. Technical Section Theory A unified booking system based on AI-driven travel recommendations and plans pivots the focus of TripAdvisor away from being just a reference point for the user in their travels. This makes way for personalization, making TripAdvisor more versatile. A study on the relationship between AI and user satisfaction emphasizes that “tourists’ trust in the big data and AI-based PTR system increased with perceived personalization, visual appearance, and information quality.” (Yang, Xinran, et al). The current state of the application ignores user needs, cutting off important details that 5 AI-Driven Booking Ecosystem Proposal users want to be exposed to. Implementation of AI recommendation and booking is a critical missing feature of the app. Benefits Augmenting AI-driven personalized booking options will enhance user experience, merge and ease the booking process, and increase customer loyalty and result in three main proven benefits: 1. Making TripAdvisor cater to all the user’s booking needs for their personalized plans will increase user satisfaction making it a preferred platform for users. We can enhance user engagement through a better user experience just as been clarified in a rigorous study, “Over three-quarters of consumers (76 percent) said that receiving personalized communications was a key factor in prompting their consideration of a brand, and 78 percent said such content made them more likely to repurchase.” (Arora et al.) Imagine a traveler receiving an intelligently curated itinerary based on their preferences, interests, and past experiences. This level of personalization won’t only boost satisfaction but also foster loyalty to TripAdvisor. In another study it was found that “tourists’ trust in the big data and AI-based PTR system increased with perceived personalization, visual appearance, and information 6 AI-Driven Booking Ecosystem Proposal quality.”(Yang et al. ) Travelers need assurance that the recommendations provided are both accurate and trustworthy, and this trust can be built through personalization. Building on these insights, it’s essential for TripAdvisor to refine its personalization strategies continually. The platform can further tailor recommendations and content to match each traveler’s unique preferences by harnessing the power of AI and its fine-tuned models. 2. Making TripAdvisor the preferred booking platform will inevitably increase loyalty and preference for TripAdvisor’s system. Based on insight from a recent study it was discovered that “when users believe that using MHB (Mobile Hotel Booking) technology fits well their lifestyle and fits well the way they like to book a hotel room, then they find MHB convenient and easy to use and thus are willing to continuously use MHB and recommend it to others.” (Ozturk et al.) By integrating flights, accommodations, activities, and transportation into a one-stop platform, TripAdvisor can address the inconvenience that users often find elsewhere. This convenience will not only attract new users but also keep them coming back. Researchers have stated: “Our results provided empirical support for the existence of all main effects (H1, H2, H3, H4, and H5 were supported), thereby 7 AI-Driven Booking Ecosystem Proposal confirming that monetary, quality-of-benefits, social status, information, and preference values share a significant positive association with purchase intention toward OTAs.” (Talwar et al.) TripAdvisor’s comprehensive approach can boost conversion rates, translating to higher revenues. A one-stop platform for all travel needs will improve the user experience and incentivize more bookings. The outcome will ultimately be growth and a cycle of recurring users building an ecosystem of happy travelers who left satisfied and looking forward to their next experience booking a trip with TripAdvisor. 3. Revenue will see an increase through the data that AI will be assessing. Leveraging user-provided data and history for informed personalized marketing will increase revenue as reported “78% of organizations that follow a data-driven approach verify an increase in lead conversion and customer acquisition.” (Awan) By utilizing user data, TripAdvisor can deliver highly targeted and effective marketing campaigns. This not only benefits the business but also ensures users receive promotions and offers that are genuinely relevant to their preferences. In another study “It was found that hedonic and utilitarian features are important variables influencing future consumer decisions through relationship marketing.”(Bilgihan, et al.) And so we have the opportunity to create an emotional connection with travelers by offering 8 AI-Driven Booking Ecosystem Proposal experiences tailored to their desires, making their journey more enjoyable and memorable. Feasibility With the guidance of our Director of Engineering and our proficient team of senior engineers, all well-versed in the standards and requirements of the TripAdvisor software, we can seamlessly enhance the application’s features in an intuitive manner without causing any disruption to the familiar user experience. Users will continue to operate the app as usual, but now with the added capability of booking their desired travel destinations directly through the application. Our Director will oversee the coordination of communication with hotel systems and bookings, ensuring a successful integration through methodologies similar to those employed by online travel agencies. Leveraging the expertise of our senior engineers, particularly in the field of generative AI and its integration, we are confident that this transition will be executed promptly and efficiently. Market Size The travel industry is undergoing a transformative shift, particularly with the rise of the sharing-based economy and the increasing prevalence of smartphones. According to IBIS World, this trend is evident in the ridesharing transportation market. 9 AI-Driven Booking Ecosystem Proposal In a parallel development, the online travel industry is projected to experience remarkable growth, with an estimated revenue of nearly $1.5 trillion anticipated in the next four years, as reported by industry experts. Methodology Our suggested strategy combines collaborative efforts headed by our Director of Engineering and a team of distinguished engineers to integrate AI-driven recommendations and booking systems into TripAdvisor smoothly with a partnership with OpenAI. We place an emphasis on thorough market research and user analysis to inform the adoption of AI capabilities, beginning with an A/B testing program and gradually introducing the booking system. Our strategy relies heavily on effective connection with hotel systems, user-friendly interface design, and rapid development and deployment by our professional engineers. Continuous monitoring and improvement, made possible by user feedback loops, ensures that the evolving system remains responsive to user needs and market trends. This strategic approach ensures the integration’s practicality and promotes TripAdvisor as an innovative leader in the online travel market. 10 AI-Driven Booking Ecosystem Proposal Management Section Team and Budget The salaries arrived at in the table below are based on Glassdoor salary estimates for like positions in Silicon Valley. The total is from 24 40-hour weeks. Position Organization Name Hourly Salary Total Salary Director, Software Engineering Hopper Michael Curtis $300 $288,000 Principal Software Engineer AirBnB Sean Glover $250 $240,000 Senior Software Engineer TripAdvisor Joey Engelhart $170 $163,200 Senior Software Engineer TripAdvisor Yash Gazula $170 $163,200 3rd Party AI Models OpenAI Total: $146,000 $1,000,000 Schedule Implementation will be broken down into four phases. Weeks Phase Description 1-4 Thorough examination and documentation of system needs All members alongside the collection of necessary AI and booking resources, to lay the foundation for subsequent development. Requirements Analysis and Resource Collection Team Members 11 AI-Driven Booking Ecosystem Proposal 5-11 Design and Prototyping System’s architecture is meticulously designed, and prototype models are created to visualize and validate the proposed structure before full-scale implementation. 12-20 Implementatio Software development takes place to bring the envisioned n features to life. 21-24 Testing and Deployment Engineers All members Rigorous testing to identify and rectify any issues, following Engineers which it is deployed for operational use. Conclusion The transformation of TripAdvisor into a comprehensive one-stop platform, integrated with AI-driven personalized travel itineraries and recommendations, holds immense promise. By addressing the current limitations in the industry, we can enhance user engagement, satisfaction, and revenue potential. It is an opportunity to redefine the travel industry and secure TripAdvisor’s position as a market leader. By harnessing AI-driven personalized travel experiences, TripAdvisor can not only redefine the travel industry but also significantly increase user engagement, satisfaction, and revenue, ultimately securing its position as a market leader. Our budget and team members make it highly feasible to embark on and complete this transformation within the 24 weeks appointed. 12 AI-Driven Booking Ecosystem Proposal Works Cited Arora, Nidhi, et al. “The Value of Getting Personalization Right-or Wrong-Is Multiplying.” McKinsey & Company, 12 Nov. 2021, www.mckinsey.com/capabilities/growth-marketing-and-sales/our-insights/the-v alue-of-getting-personalization-right-or-wrong-is-multiplying. Bilgihan, Anil, and Milos Bujisic. “The Effect of Website Features in Online Relationship Marketing: A Case of Online Hotel Booking.” Electronic Commerce Research and Applications, vol. 14, no. 4, 2015, pp. 222–232, doi:10.1016/j.elerap.2014.09.001. Global Business Travel Industry Forecast Is for Accelerated Rebound, Spending to Reach $1.8 Trillion by 2027 – Global Business Travel Association.” GBTA, Global Business Travel Association, 23 Aug. 2023, www.gbta.org/global-business-travel-industry-forecast-is-for-accelerated-rebo und-spending-to-reach-1-8-trillion-by-2027/. Muhammad Bilal Awan. “Data-Driven Marketing for Better Roi.” Data Science Dojo, 27 Oct. 2022, datasciencedojo.com/blog/data-driven-marketing/. Ozturk, Ahmet Bulent, et al. “What Keeps the Mobile Hotel Booking Users Loyal? Investigating the Roles of Self-Efficacy, Compatibility, Perceived Ease of Use, 13 AI-Driven Booking Ecosystem Proposal and Perceived Convenience.” International Journal of Information Management, vol. 36, no. 6, 2016, pp. 1350–1359, doi:10.1016/j.ijinfomgt.2016.04.005. Talwar, Shalini, et al. “Why Do People Purchase from Online Travel Agencies (Otas)? A Consumption Values Perspective.” International Journal of Hospitality Management, vol. 88, 2020, p. 102534, doi:10.1016/j.ijhm.2020.102534. Yang, Xinran, et al. “Personalized Tourism Recommendations and the E-Tourism User Experience.” Journal of Travel Research, 2023, doi:10.1177/00472875231187332. 14 Proposal for: Customized “For You Page” Prepared by: Kevin Yu System Name: TikTok Abstract: In modern times, the internet has increasingly gained popularity, and social media has taken over the world. Its impact increases every year, and it influences how people think and learn. TikTok, the first social media platform involving the scrolling of short one to three minute videos, revolutionized how social media content is viewed and consumed today. The platform uses an algorithm to determine what videos to show users on the “For You Page”, and every user of TikTok adheres to this algorithm. Although the algorithm is effective for many users, it is not always effective for others as it constantly shows videos with different topics and lengths, which users may not like. To combat this, Arman Khondker, Kaixin Xiao, and I are proposing that TikTok should create a customizable “For You Page” where users select specific topics in order to be fed a consistent stream of content. Users may have access to both the original “For You Page” to see new trending content, and they will also be able to view their own “For You Page” which would feature content they select. 1 Table of Contents Abstract.………………………………………………………………………………………….1 List of Figures.……………………………………………………………………………………2 Introduction.………………………………………………………………………………………3 System Overview………………………….…………..…………………………………3 Problem.…………………………………………………………………………………..3 Solution.…………………………………………………………………………………..3 Technical Section ……………………………………………………………………………..…4 Theory.……………………………………………………………………………..…….4 Benefit.……………………………………………………………………………………4 Feasibility.……………………………………………………………………………..…6 Market Size.………………………………………………………………………………6 Method of Approach……………………………………………………………………..6 Management Section.…………………………………………………………………………….7 Team………………………………………………………………………………………7 Schedule………………………………………………………………………………….7 Budget…………………………………………………………………………………….8 Conclusion……………………………………………………………………………………….8 References……………………………………………………………………………………….10 List of Figures Figure 1: Table of Team Members……………………………………………………………….7 Figure 2: Table of Project Schedule………………………………………………………………7 Figure 3: Table of Salary Costs…………………………………………………………………..8 2 Introduction System Overview: TikTok is a social media platform that allows users to see other users’ short videos and allows users to upload their own short videos. Users will be subject to short ten seconds to three minute videos that the user can constantly scroll through. The videos are shown on a page called the “For You Page”, and they are determined by an algorithm that decides what the user will see next. Overall, Tiktok has over one billion worldwide users from around the world, and according to Statista, it accounts for 20% of internet users worldwide. Problem: In TikTok’s current “For You Page”, videos are shown to users by the use of an algorithm. As a result, users get constantly changing videos of varying topics that they may or may not like. For example, users may be shown the latest trend going around the world. Although TikTok has a “Following” tab which shows users videos of content creators that they follow, it does not show any new content from different creators in the same topic or field. The “For You Page” and “Following” tab both have their issues. One is too specific while the other is too broad. Solution: By adding a customizable and separate “For You Page” that does not run on the normal TikTok algorithm, users of TikTok may input their own content preferences, leading to a more consistent stream of content that they will like. Users will be able to explore and discover new content creators and content of similar topics. The result is a happy medium that features new content in a specific topic range. As a result, the new feature would not have a super wide range of content, and it is also not limited to specific content creators. 3 Technical Section Theory: By adding a customizable and separate “For You Page” that does not run on the TikTok algorithm, users of TikTok may input their own content preferences, leading to a more consistent stream of content that they will like. As a result of the personal feature, TikTok will be able to send specialized ads generating more income, increase its usability raising user loyalty, and increase customizability leading to more users. Benefits: Adding this customization feature would not only help TikTok earn more revenue, but it would also allow TikTok to keep and attract more users to the platform. 1. Adding a customizable “For You Page” TikTok may target specialized advertisements towards their user, generating more income for the company. A study conducted by Jiang and Wu compared the benefits of targeted advertising and mass advertising. In its conclusion the study stated, “This result indicates that the targeted advertising might induce intensified competition. In all, we show that the most efficient free-entry outcome occurs when the targeting precision is moderate. In other words, neither mass advertising nor perfect advertising leads to a less efficient outcome” (Jiang and Wu). The reason that moderate targeting precision was deemed the most effective was due to the money in to money out ratio. As companies spent more money finding user’s interest, the money produced back from the advertisements eventually staggered and dropped, which is the reason that a moderate targeting precision level was deemed optimal. In the case of TikTok, the company would be able to save money on advertising 4 precision because users are already selecting topics they like. As a result, they would have low targeting costs as well as higher profits. 2. A customizable “For You Page” adds usability for the application and will lead to higher user satisfaction. A study conducted by Dianat et al. showed this direct correlation, it stated, “User satisfaction was also influenced by Web design attributes… Among the web design attributes, Web structure showed the strongest association with user satisfaction, followed by layout, personalisation, search and performance” (Dianat et al.). Adding the customizable “For You Page” to TikTok adds to the platform’s usability, which would increase the overall user satisfaction of the platform. 3. Adding customizability and differentiation leads to a more successful platform by raising user loyalty and attracting more users. As stated in a study analyzing application innovation and success, “Customers will look for products from other companies they feel like can satisfy them. For this reason, continuous innovation is needed”(Farida and Setiawan). Implementing the customizable “For You Page” aids in the innovation of the platform, keeping the user satisfied and engaged. In addition to a more satisfied user, “If product or service is unique, this strategy provides high customer loyalty” (Mustafa and Islami). By adding the customizability feature, TikTok will differentiate itself from its competitors, and it will keep their users while also appealing to other social media users looking for specific features. 5 Feasibility: Adding a separate tab for a customizable “For You Page” is very feasible as they have added the “Following” tab and the regular “For You Page” tab. The customizable page is very similar to the other two, and it will only feature a different algorithm. With the knowledge of TikTok’s platform and the backend development expertise of Arman Khondker, the implementation of the customizable “For You Page” will be a swift and simple task. The only new screen that must be added is a tab where users can enter topics that they would like to see, which is an easy addition. The implementation of this screen will be handled by Kaixin Xiao, a frontend engineer at TikTok with vast experience in implementing tabs. A fully functional customizable “For You Page” would give the user the topic screen, and it would then operate like TikTok’s current “For You page. The videos that are chosen to be shown to the user will be displayed by a different algorithm. Market Size: According to Statista, the social media market is worth around 140 billion dollars, and it is growing each year. From 2022 to 2023 alone, the market increased by 12 percent, and it is projected to keep growing in the upcoming years. Out of the total market, DemandSage found that Tiktok makes up around 22.4% of all social media users on the internet. Adding the customized “For You Page” will add room for more growth and greater profits. Method of Approach: Arman Khondker will utilize his backend expertise and experience working with TikTok’s algorithm to lead the addition of a new algorithm of TikTok by editing and tweaking 6 parts of the previous algorithm. He will create the new algorithm, and he will then implement that algorithm with the existing user interface of TikTok. With Kaixin Xiao’s experience in front end development with TikTok, she will be in charge of reading user input for topics they would like to see. Kaixin will read and store users’ input and will pass the data to Arman, which he will use in his new algorithm. Management Section Team Name Organization Qualifications Arman Khondker TikTok Back-end engineer at TikTok. Worked directly with the TikTok algorithm. Kaixin Xiao TikTok Front-end engineer at TikTok. Experience in creating new tabs and screens. Fig 1: Table of Team Members Arman Khondker and Kaixin Xiao are ideal members for the job. They are extremely qualified and have the experience that perfectly suits the project. Both members have directly worked with the TikTok application, and they have had years of experience working in the field. Schedule Implementing the customized “For You Page” will take around 6 weeks. The project will follow an agile methodology approach and will feature 6 phases. Week Phase Description Team Members 1 Planning Discuss the method of approach. Add ideas for effective implementation. All team members 7 2 Designing Create and Implement the tab that reads and Kaixin Xiao and her outputs user input. team 3 Developing Tweak the current TikTok algorithm to suggest videos within a certain topic range that the user selects. Arman Khondker and his team 4 Testing Combine both part 2 and 3 and test if the full feature works properly. All team members 5 Deploying Add the feature to the app and record user feedback. All team members 6 Reviewing and Tweaking Make changes based on user feedback . All team members Fig 2: Table of Project Schedule Budget: Team members will work full time, 40 hour work weeks. According to Glassdoor, the total estimate of the project will be around $33,120. Position Name Hourly Salary Total Salary (40 Hours / Week) Backend Engineer Arman Khondker $85 $20,400 Frontend Engineer Kaixin Xiao $53 $12,720 Total $33,120 Fig 3: Table of Salary Costs Conclusion TikTok has a massive audience and influence in the social media industry. It has revolutionized the consumption of short form content, and it has changed the way people learn today. Adding a customized “For You Page” will add application usability, raise user satisfaction, 8 and separate TikTok from competitors. As a result of this feature, TikTok will attract more users while also generating more profits. 9 References Dianat, Iman et al. “User-centred web design, usability and user satisfaction: The case of online banking websites in Iran.” Applied ergonomics vol. 81 (2019): 102892. https://doi.org/10.1016/j.apergo.2019.102892 Ganesh Iyer, David Soberman, J. Miguel Villas-Boas, (2005) The Targeting of Advertising. Marketing Science 24(3):461-476 https://doi.org/10.1287/mksc.1050.0117 Ida Farida, Doddy Setiawan, Business Strategies and Competitive Advantage: The Role of Performance and Innovation, Islami, X., Mustafa, N. & Topuzovska Latkovikj, M. Linking Porter’s generic strategies to firm performance. Futur Bus J 6, 3 (2020). https://doi.org/10.1186/s43093-020-0009-1 Journal of Open Innovation: Technology, Market, and Complexity, Volume 8, Issue 3, 2022, 163, ISSN 2199-8531, https://doi.org/10.3390/joitmc8030163. Jiang, Z., & Wu, D. (2022). Targeting Precision in Imperfect Targeted Advertising: Implications for the Regulation of Market Structure and Efficiency. SAGE Open, 12(1). https://doi.org/10.1177/21582440221082132 Tsai, HT., Chien, JL. & Tsai, MT. The influences of system usability and user satisfaction on continued Internet banking services usage intention: empirical evidence from Taiwan. Electron Commer Res 14, 137-169 (2004) https://doi.org/10.1007/s10660-014-9136-5 10 TikTok Harm Detection Proposal Proposal for: Misinformation and harm Detection System Prepared by: Matthew Hoffman System name: TikTok Abstract TikTok’s short-form videos have led to it having a meteoric rise in popularity, taking a part of the daily lives of many. However, with this popularity, there have been well-known negative externalities. Misinformation, challenges, and even positive content about harmful products lead to both harm for users and negative attention from the public and government. Google co-founder Larry Page, YouTube co-founder Jawed Karim, and I are proposing a machine learning system which can detect this harmful content and alert the moderation team, which should reduce the spread of misinformation, prevent harm to users, and reduce outside calls for regulation. 2 Table of Contents ABSTRACT……………………………………………………………………………………….2 List of Figures……………………………………………………………………………………..3 INTRODUCTION…………………………………………………………………………………4 System Overview………………………………………………………………………….4 Problem……………………………………………………………………………………4 Solution……………………………………………………………………………………4 TECHNICAL SECTION………………………………………………………………………….5 Theory……………………………………………………………………………………..5 Benefits……………………………………………………………………………………5 Feasibility………………………………………………………………………………….6 Market Size………………………………………………………………………………..7 Method of Approach………………………………………………………………………7 MANAGEMENT SECTION………………………………………………………………………8 Team……………………………………………………………………………………….8 Schedule……………………………………………………………………………………8 Budget……………………………………………………………………………………..9 CONCLUSION……………………………………………………………………………………9 REFERENCES…………………………………………………………………………………..10 List of Figures Figure 1: Mockup of user view……………………………………………………………………7 Figure 2: Table of team members…………………………………………………………………8 Figure 3: Table of project schedule………………………………………………………………..8 Figure 4: Table of Budgets…………………………………………………………………………9 3 Introduction System Overview TikTok is a mobile and web-based video hosting platform specialized in short-form videos. To facilitate this, it provides a system for uploading videos on both the web and mobile versions, along with a feature for recording and making some edits to videos on the mobile version. Once uploaded, TikTok’s algorithm may show that video to users when they’re scrolling on the “For You” page, along with having the video available through a direct link and the creator’s page. Each video has a length limit of 10 minutes. Problem TikTok’s video style of having quick, flashy videos which reward attention-seekers contributed to its success. However, it is also conducive for the spread of misinformation, harmful challenges, and inflammatory content. These can be much shorter than their counterparts due to the content being more attention-grabbing and needing less time due to a lack of nuance. The resulting harm has both killed people and drawn public ire towards TikTok. Solution Implementing an automated machine-learning system to detect when a video contains undesired and harmful content and alerts moderation staff can help solve the issue. The system can be taught to detect misinformation, harmful challenges, or promotion of harmful behaviors. Whenever a video is uploaded, this system would scan the video, and on detecting any of the above, would temporarily freeze the upload until a moderator takes action. By preventing these from even showing up, the harm and bad attention can be greatly reduced. 4 Technical Section Theory Implementing an automated system to detect harmful content will easily allow for detection and removal of undesired content from the platform. Without it, TikTok presently allows for misinformation, harm, and outside ire. As such, its implementation is critical for the safety of the platform and its users. Benefits Implementing a system to scan videos for misinformation or promotion of dangerous actions and halt their upload can provide TikTok and its users with three overall benefits: 1. Preventing the upload of misinformation can prevent its spread, through both TikTok and overall society. Preventing misinformative videos from being uploaded means misinformation is spread less. A study on how social media impacts vaccine misinformation found that “the combination of social media and the wide availability of highly legitimized forms of misinformation has accelerated its diffusion” (Di Domenico, et al.). Social media is a very strong vector for the spread of misinformation, and TikTok, being potentially the fifth most widely used social media platform, is a major potential player in this field. As such, TikTok directly addressing misinformation can have a strong positive impact, cutting off a major route through which misinformation could otherwise spread. 2. Preventing the upload of videos promoting harm can increase user’s safety On top of the safety that comes from preventing misinformation that would lead to people avoiding medical treatment and vaccines, there’s also safety from preventing things that lead to 5 harm. A case study about the Benadryl Challenge, which started circulating on TikTok in 2020 and which has continued since, reported that “teens have presented to emergency departments in Canada and the United States in various states of intoxication after taking high doses of diphenhydramine because of these social media “challenges,”…[with] at least one reported death,” (Elkhazeen et al). This case study was even in 2022, before the 2023 case of a 13 year old dying from a seizure due to attempting this “challenge.” TikTok’s 40 thousand safety professionals were unable to prevent this challenge from continuing to spread even after several years, resulting in more life being lost, and this is far from the only challenge. Were the proposed system in place, that moderation staff would have been significantly more likely to stop the video which led to the user attempting this challenge and subsequently dying. 3. Preventing misinformation and harm will help TikTok prevent regulatory oversight. TikTok is familiar with governments attempting to regulate and ban its usage by this point. Part of what leads to governments regulating TikTok is public pressure, caused by the harm TikTok plays a role in spreading. A study about materials promoting e-cigarette usage on TikTok openly stated that “Government regulation that captures e-cigarette advertising, promotion and sponsorship, including on social media, is needed” (Jancey et al.). Material which harms users draws negative attention, and that negative attention is exactly why governments may seek to place regulations on TikTok. Some degree of effective self-regulation, which this autonomous system provides, is required for convincing both the public and the lawmakers that governmental regulation is not required. Feasibility Implementation of this automated system will be moderately difficult, but with the skill and knowledge of Google co-founder Larry Page and YouTube co-founder Jawed Karim, the 6 task will be approachable. The user won’t need any new pages on their end, with the only modification being an alert to when a video’s upload is on hold, and whether the hold is lifted or the video is outright prevented from uploading. The largest challenge is creating the system for machine learning, training it, and integrating with TikTok and its report and flagging systems. Market Size TikTok has a strong market hold, with Business of Apps reporting that TikTok has around 1.5 billion monthly users in 2023, and that its 2022 revenue is estimated to be $9.4 billion. Even with this wide user base, TikTok falls behind several other Figure 1: Mockup of user view social media platforms in terms of monthly active users. However, its user base is expected to grow to 2 billion by the end of 2024. Method of Approach Jawed Karim will apply his experience in designing aspects such as PayPal’s anti-fraud system to the design and planning of the system’s backend, while Larry Page will apply his experience creating and running Google to design how the system will interface with both users and moderation staff. Figure 1 depicts a mockup of what a user may see when uploading a video if the system detects harm or misinformation. Options have been grayed out to show that the upload has begun, but has been frozen. 7 Management Section Team Name Organization Qualifications Jawed Karim YouTube(former) Designed PayPal’s anti-fraud system, co-founded YouTube site, MS in computer science from Stanford University Larry Page Alphabet Former co-founder and CEO of Google and Alphabet, MS in computer science from Stanford University Figure 2: Table of team members Jawed Karim and Larry Page are both educationally qualified and heavily experienced in fields which are valuable for projects working together with a system such as TikTok. Schedule Implementation of the machine learning misinformation & harm detection system will take an estimated 20 weeks. The project will follow an agile development model, with most of those weeks set in cyclical 4-week periods. Weeks Phase Description Team Members 1 Initial planning Given objective, plan ideas for how it should work and what it must look out for All (1 team) 2 Initial modeling Model the processes, front and back end All (1 team) 3-6 Initial coding Implementation of code, following plan and model All (2 teams) 7, 11, 15, 19 Testing Test with QA and moderation teams Larry Page 8, 12, 16 Plan and model Plan and model changes based on tests All (1 team) 9-10, 13-14, 17-18 Further coding Implement changes to code in line with revised plan and model All (2 teams) 20 Deployment Deploy and integrate system Jawed Karim Figure 3: Table of project schedule 8 Budget Team members will work 40 hours per week. Figures are estimated using the high end estimate on Glassdoor, based on the TikTok LA office location, of $185k annual. Pay divided by the hours expected to be worked by someone working a half of a year, rounded up, for the hourly salary. Position Name Hourly Salary Total Salary Software Engineer Larry Page $180 $136,000 Software Engineer Jawed Karim $180 $115,200 Total $251,200 Figure 4: Table of Budgets Conclusion TikTok is a very powerful competitor in the social media market, but its current lack of strong automated moderation puts it at risk of being held back by its harm to users causing bad public relations and potential government regulation. The long-term benefits of implementing such an automated system will promote the product’s growth. 9 References Di Domenico, Giandomenico, et al. “Marketplaces of Misinformation: A Study of How Vaccine Misinformation Is Legitimized on Social Media.” Journal of Public Policy & Marketing, vol. 41, no. 4, 2022, pp. 319–35, https://doi.org/10.1177/07439156221103860. Elkhazeen, Abu, et al. “A TikTokTM ‘Benadryl Challenge’ death—A Case Report and Review of the Literature.” Journal of Forensic Sciences, vol. 68, no. 1, 2023, pp. 339–42, https://doi.org/10.1111/1556-4029.15149. Iqbal, Mansoor. “Tiktok Revenue and Usage Statistics (2023).” Business of Apps, Business of Apps, 31 Oct. 2023, www.businessofapps.com/data/tik-tok-statistics/. Jancey, Jonine, et al. “Promotion of E-Cigarettes on TikTok and Regulatory Considerations.” International Journal of Environmental Research and Public Health, vol. 20, no. 10, 2023, p. 5761–, https://doi.org/10.3390/ijerph20105761. 10
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Buddhist Theories on Meditation Within the Doctrinal Contexts of Indian and East Asian Buddhist Traditions Essay

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REL 3349 Buddhist Meditation Discussion of “Yoga, Brief History of an Idea” Thesis? What is Yoga? Yoga Sutras of Patañjali Visuddhimagga Yogadṛṣṭisamuccaya By the , however, the core principles of yoga were more or less in place, with most of what followed being variations on that original core: 1. Yoga as an analysis of perception and cognition. [Yogācāra Buddhism 4th c.] 2. Yoga as the raising and expansion of consciousness. [Mahābhārata; Mahayana and Jain soteriology] 3. Yoga as a path to omniscience [Nyaya-Vaisesika; Mahayana, Jain, Theravada, Sarvastivada, etc. ] 4. Yoga as a technique for entering into other bodies, generating multiple bodies, and the attainment of other supernatural accomplishments. [rise of Tantric Buddhism, YS, etc. ] NY Times: “It’s time to roll out your yoga mat and discover the combination of physical and mental exercises that for thousands of years have hooked yoga practitioners around the globe. The beauty of yoga is that you don’t have to be a yogi or yogini to reap the benefits. Whether you are young or old, overweight or fit, yoga has the power to calm the mind and strengthen the body.“ Webster’ s Dictionary: A system of physical postures, breathing techniques, and sometimes meditation derived from Yoga but often practiced independently especially in Western cultures to promote physical and emotional well-being. Swami Vivakananda: Indian Guru Who Brought Eastern Spirituality to the West Anagārika Dharmapāla (1864 – 1933) was a Sri Lankan Buddhist revivalist and a writer who presented at the first World Parliament of Religion in 1893, representing Buddhism. During his speech, “Buddhism” was presented as a contemplative, gentle, and rational religion, completely compatible to science, that predated Christianity. REL 3349 Buddhist Meditation Cosmic Context Saṃsāra 12 Link Chains of Dependent Origination 1. Ignorance 2. Formation 3. Consciousness 4. Name and form 5. Six senses 6. Contact 7. Sensation 8. Craving 9. Grasping 10.Becoming 11.Birth 12.Old age and death Past Present Future greed Lower Realms hatred ignorance THREE POISONS Karma and Psychology karma Five conditions of karma (p.120): 1. A living being 2. knowing that the being is living 3. Intention for action towards it 4. Action is done 5. Being is actually harmed * Karma is the fuel of saṃsāra. Mind is the precursor of karma. Purification of mind frees one from saṃsāra. Historical Context The Buddha: Awakened One • Buddha vs. arhat, śrāvaka, pratyekabuddha, and bodhisattva? The Buddha awarenesses events. Lumbini, east of Kapilavastu, was the birthplace of Sidhārtha Gautama (the Buddha). The Brahmanical Tradition 1. 2. 3. 4. Aryans migrated from ancient Iran to Indus valley in the beginning of the 2 millennium BCE. The Aryans supposedly brought with them the Vedas, the corpus of sacred religious-ritual literature, detailed a particular vision of the world and society: ritual purity and caste system. Ritual purity: society reflects a hierarchy of ritual purity Caste system (varna): • – Brāmins: priests • – Kşatriyas: rulers • – Vaiśyas: merchants • – Śūdras: servants The Alternative Tradition: 1. Śramaṇa: one who “strives” spiritually. Also called the samnyāsin, or a renouncer (of the household life), or religious mendicant. 2. This counter movements to the hegemony of the Vedic tradition consists of many different groups: Widespread by the 5th BCE, these mendicant groups may be characterized by three features: • Asceticism • Meditative/contemplative: (dhyāna) or concentration; absorption (samādhi). • Philosophical: views of existence 3. Examples: Jains (ascetics), Ājīvakas (determinalist), Charvakas or Lokāyata (materialists), and the Ajñanas (skeptics). 4. The historical Śākyamuni Buddha was part of this śramaṇa mendicant tradition. Timeline Aryans migrated from ancient Iran to Indus valley. Vedic texts form from 1500-500 BCE. 2 millennium BCE Buddhism transmits to China and lasts for 1000 years. By 4th CE, Buddhism goes to Korea; 6 CE goes to Japan. Birth of Siddharma Gautama, Śākyamuni Buddha 1 millennium BCE 5th BCE Emergence of the śramaṇas, the counter-mainstream movement of contemplatives. 1000 BCE to the Buddha’s time. 3rd BCE Aśoka conquers and unites the Indian subcontinent and more; great patron of Buddhism. Buddhism goes to Sri Lanka. 1st CE Dharma O R D I N A RY M E A N I N G U LT I M AT E M E A N I N G Dharma, also as…. T E XT S C ANON Four Noble Truths Suffering or dissatisfaction (duhkha): pain, anguish Cause: greed/craving, aversion, delusion (three poisons) Cessation: nirvāṇa or a) extinction of the three poisons; b) final condition of the Buddha; c) awakening Path: systems of training such as: the Three Higher Trainings; the eightfold path of right view, intention, speech, action, livelihood, effort, mindfulness, concentration; six or ten perfections Analogy: a doctor’s diagnosis of an illness. The Three Higher Trainings Three higher Trainings Eightfold Path right view Morality (śīla) right intention right speech Meditation (samādhi) right action right livelihood Wisdom (prajñā) right effort right mindfulness right concentration No-Self, Anātman ātman or self is the Upaniṣadic notion of ultimate, unchanging substrate that underlies all experiences. Buddhism denies its existence and proposes that the self is only a psycho-somatic phenomena of the five skandhas: form, sensation, perception, volition, consciousness. REL 3349 Buddhist Meditation Buddhist Systems of Meditation Śamatha Vipaśyanā Śamatha Five Methods of Stilling the Mind Mindful recollection of the breath Meditation on impurity Meditation on the four boundless states Meditation on causes and conditions Meditation on buddha Obscurations to meditation Treatises on meditation often cite mental distraction and dullness as the most basic impediment to the development of samādhi. Subjected to a slightly more detailed analysis, they are expanded into a set of five basic obstacles known as the five types of mental “covering;’ or “obscuration“ (S. nivaraṇa): • desire • anger • dullness • distractedness and remorse • doubt/torpor/fear They are called coverings or obscurations because they color the mind’s activity and conceal its intrinsic potential for concentration and wisdom. Śamatha Five Methods as Antidotes Mindful recollection of the breath Meditation on impurity Meditation on the four boundless states Meditation on causes and conditions Meditation on buddha Breath… Counting: 1-10 on each exhalation; reverse counting (and skipping a number) Following: nostrils, abdomen, whole body Concentrating: the “elixir fields” (C. dantian) Impurity… Other: internal organs; decomposition of a corpse Self: internal organs; decomposition of a corpse Real or visualized. Leading to progressive stages of concentration…. Buddha… Intoning Reciting Visualizing – glorified (physical) form/attributes – merit or spiritual qualities (4 dimensions) – ritualization Four boundless states… Causes and Conditions… Meditation on cause and condition is divided into four parts: (I) contemplation of existence and nonexistence; (2) contemplation of the three states of time; (3) contemplation of space; (4) contemplation of motion. REL 3349 Buddhist Meditation Rise of Mahāyāna Buddhism Earliest Mahāyāna (“Great Vehicle”) scriptures possibly date back to 1 BCE; this date is pushed back from Chinese translations of the texts by Lokaksema in the 2 CE and extant fragments of Sanskrit scriptures from the 1 CE. The production of Mahāyāna scriptures span for roughly 6-7 centuries. Earliest Mahāyāna scripture: Aṣṭasāhasrikā Prajñāpāramitā Sūtra or “Perfection of Wisdom in 8,000 Lines.” Scholarly Theories of Its Origin 1. 2. 3. 4. Early view: Mahāyāna was in competition with Hīnayāna schools (evolved from Mahāsaṃghikā) Early view: Mahāyāna was a devotional movement (stūpa worship), hence must be a “lay movement” Current view: Mahāyāna came out of the forest dwelling tradition of ascetic monks who sought to revive the spirit of Śākyamuni Buddha in the path he took as a bodhisattva Current view: Mahāyāna arose out of a cult of the book Features of the Mahāyāna Pāramitās: compassion wisdom nirvāṇa buddhahood 1. Giving dāna 2. Morality śīlā 3. Patience kṣānti 4. Fortitude virya 5. Meditation dhyāna 6. Discernment prajñā 7. Skillful means upāya 8. Vow, resolution, aspiration, determination praṇidhāna 9. Spiritual power bala 10. Knowledge jñāna Insight Meditation: Vipaśyanā (Pali: vipassana) Vipaśyanā: a set of techniques that are designed specifically to generate liberating insight into no-self, no-mind, and emptiness. Much of the Mahāyāna practices remain the same as early Buddhism: Early Vipaśyanā (Pali: vipassana) Satipaṭṭhāna sutta (Foundations of Mindfulness): Body Sensations Mind Dharmas Mahāyāna Vipaśyanā The Four Stations of Mindfulness entails contemplation of four basic objects: • • • • the gross physical body Sensation the mind dharmas, or elemental units of psycho-physical experience that constitute experience of body, sensation, and mind. Purpose of the Four Stations of Mindfulness Rupert Gethin An OPUS book The Foundations of Buddhism Rupert Gethin is Lecturer in Indian Religions in the Department of Theology and Religious Studies, and co-director of the Centre for Buddhist Studies, at the University of Bristol. He is author of The Buddhist Path to Awakening (1992) and is a specialist in Theravada Buddhism. OPUS General Editors Christopher Butler Robert Evans John Skorupski OPUS books provide concise, original, and authoritative introductions to a wide range of subjects in the humanities and social sciences. They are written by experts for tlie general reader as well as for students. The Foundations of Buddhism Rupert Gethin Oxford New York OXFORD UNIVERSITY PRESS OXFORD UNIVERSITY PRESS Great Clarendon Street, Oxford oxz 6DP Oxford University Press is a department of the University of Oxford. It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide in Oxford NewYork Auckland Cape Town Dar es Salaam Hong Kong Karachi Kuala Lumpur Madrid Melbourne Mexico City Nairobi New Delhi Shanghai Taipei Toronto With offices in Argentina Austria Brazil Chile Czech Republic France Greece Guatemala Hungary Italy Japan South Korea Poland Portugal Singapore Switzerland Thailand Turkey Ukraine Vietnam Oxford is a registered trade mark of Oxford University Press in the UK and in certain other countries Rupert Gethin © 1998 The moral rights of the author have been asserted Database right Oxford University Press (maker) First published as an Oxford University Press paperback 1998 All rights reserved. No part of this publication· may be reproduced, stored in a retrieval system, or transmitted, in ariy,fonn or by any means, without the prior permission in writingpf,Oxford Ul).iversity Press, or as expressly permitted by law, or under tenhs” agreed With the appropriate reprographics rights organization. Enquiries concerning reproduction outside the scope of the above should be sent to “the Rights Department, Oxford University Press, at the address above You must not circulate this book in any other binding or cover and you must impose this same condition on any acquirer British Library Cataloguing in Publication Data Data available Library of Congress Cataloging in Publication Data Gethin, Rupert. The foundations of Buddhism f Rupert Gethin. Includes index. 1. Buddhism. I. title. BQ4012.G47 1998 294.3-dc21 98-12246 ISBN 0-19-289223-1 11 Typeset by Graphicraft Typesetters Ltd., Hong Kong Printed in Great Britain by Clays Ltd, St Ives pic For my mother Acknowledgements My understanding of the Buddhist tradition owes much to many. Some of what is owed and to whom is apparent from the notes and bibliography of the present volume, but some deserve special mention. To Lance Cousins, who first introduced me to Buddhism, I owe a special debt. A number of people have read drafts of parts of this book during the course of its writing; to Lance Cousins, Hugh Gethin, Michael Houser, Rita Langer, Ken Robinson, Alexander von Rospatt, Ornan Rotem, Gregory Schopen, and Paul Williams I am especially grateful for their comments, criticisms, and encouragement. I am also grateful to my students and all those others whose questions and puzzled faces have prompted me to try to express what I understand of Buddhism more clearly. Finally a word of thanks to my editor at OUP, George Miller, for his patience and help. siddhir astu subham astu Contents List of Tables and Figure xii List of Maps xiii A Note on Buddhist Languages xvii INTRODUCTION I THE BUDDHA: THE STORY OF THE AWAKENED ONE The historical Buddha The legend of the Buddha The nature of a buddha 7 7 r6 27 2. THE WORD OF THE BUDDHA: BUDDHIST SCRIPTURES AND ScHOOLS Dharma: texts, practice, and realization The first recitation of scriptures · SUtra and Abhidharma The origin of the ancient Buddhist schools The Mahayana sUtras 35 35 39 45 49 56 I. 3· FouR TRUTHS: THE DISEASE, THE CAUSE, THE CuRE, THE MEDICINE The orientation of the Buddha’s teaching The disease of suffering 59 59 6o The origin of suffering: attachment, aversion, and delusion 68 The cessation of suffering: nirvaQ.a 74 The way leading to the cessation of suffering 79 4· THE BuDDHIST CoMMUNITY: MoNKS, NuNs, AND LAY FOLLOWERS 85 The Buddha’s followers and the origin of the Buddhist order 85 X Contents Ordination and the Buddhist monastic ideal The underlying concerns of the Vinaya From wandering to settled life The spiritual life The lay community Spiro’s schema: apotropaic, kammatic, and nibbanic Buddhism 5· THE BuDDHIST CosMos: THE THRICE-THousANDFOLD WORLD Of space and time: world-systems Cosmology and psychology: macrocosm and microcosm Cosmology, folk religion, and modern science 6. No SELF: PERSONAL CONTINUITY AND DEPENDENT ARISING The Buddhist critique of self as unchanging The problem of personal continuity Ignorance, attachment, and views of the self The elaboration of the teaching of dependent arising Did the Buddha deny the existence of the self? 7· THE BUDDHISM PATH: THE WAY OF CALM AND INSIGHT Introductory remarks The role of faith Good conduct The practice of calm meditation The stages of insight meditation The relationship of calm and insight 8. THE ABHIDHARMA: THE HIGHER TEACHING Stories, legends, texts, and authors The Abhidharma as a system of Buddhist thought The consciousness process, karma, and rebirth Some Abhidharma problems 87 91 95 101 107 IIO II2 II2 II9 !26 133 133 J40 146 149 159 163 163 165 169 174 18j 198 202 202 207 215 2!8 Contents 9· THE MAHAYANA: THE GREAT VEHICLE The beginnings of the Mahayana The vehicle of the bodhisattva Transcendent buddhas Emptiness and the ‘perfection of wisdom’ Nagarjuna and the ‘middle’ (Madhyamaka) school ‘Ideas only’ (vijfiapti-miitra) and the Yogacara The Tathagatagarbha ro. EvoLVING TRADITIONS OF BuDDHISM: SouTH, EAsT, NORTH, AND WEST Theravada Buddhism in Sri Lanka and South-East Asia: Southern Buddhism China, Korea, and Japan: East Asian Buddhism Tibet and Mongolia: Northern Buddhism A final note: Buddhism in the West xi 224 224 226 231 234 237 244 250 253 253 257 266 273 &~ m Select Bibliography 302 Glossary 319 Index 323 List of Tables and Figure Tables 1. The noble eightfold path The thirty-one realms of existence according to the Pali sources 3· Dependent arising 4· The forty subjects of calm meditation according to Buddhaghosa 5· Ascending stages of calm meditation 6. The stages of insight according to Buddhaghosa’s Visuddhimagga 7. The scheme of the five paths and the ten bodhisattva stages 8. The Abhidharma Pitaka 81 2. Figure 1. The Tibetan ‘Wheel of Existence’ u6 152 178 182 193 196 205 List of Maps The Ganges basin at the time of the Buddha 2. The spread of Buddhism in the ancient world 3· Buddhism in the modern world I. xiv XV xvi MAP 1. The Ganges basin at the time of the Buddha 0 0 50 50 100 100 miles 150 km Land over 1000 metres MAP 2. 500 1000 miles 500 1000 1500 km The spread of Buddhism in the ancient world ~ The extent of Buddhist influence 0 0 0 ‘ ? JAPAN MAP 3· 500 1000 miles 500 1000 1500 km Buddhism in the.modern world Theravada or ‘southern’ Buddhism East Asian or ‘eastern’ Buddhism [::J Tibetan or ‘northern’.Buddhism 0 0 SRI LANKA a .~b ~ft-0:~! ~· ,’ .i~vf!J ~~ A Note on Buddhist Languages The original language of Buddhist thought is problematic. It was not Sanskrit (Old Indo-Aryan) but a closely related Middle Indo-Aryan dialect similar to Pali, the canonical language of the Buddhism of Sri Lanka and South-East Asia. As Buddhism developed in ancient India it tended increasingly to speak the universal language of ancient Indian culture, Sanskrit. Subsequently Buddhist texts were translated into Chinese _and Tibetan which became major Buddhist languages in their own right. The general principle I have adopted is to quote universal Buddhist terms in both Sanskrit and (when there is a difference) Pali, placed in parentheses after the English translation so: ‘aggregates’ (skandha/khandha). If the term is used again in the body of the text I have generally preferred the Sanskrit form, unless the context is exclusively that of Theravada Buddhism. Terms that are specific or characteristic of a particular Buddhist tradition are quoted in the appropriate language(s), either Pali or Sanskrit with, where appropriate, their Chinese or Tibetan, or occasionally their Japanese or Korean translation. The transliteration of Indian languages follows the standard transliteration scheme (see A. L. Basham, The Wonder that Was India, so6~8); Chinese is quoted according to the Wade~Giles system, rather than Pin-Yin, Tibetan according to the Wylie system. Words that have become part of the English language (i.e. would be found in an English dictionary) are left unitalicized but the appropriate diacritical marks have been added, hence ‘nirval)a’. Introduction The term ‘Buddhism’ refers to a vast and complex religious and philosophical tradition with a history that stretches over some 2,500 years, taking in, at one time or another, the greater part of Asia, from Afghanistan and parts of Persia in the west to Japan in the east, from the great islands of Sumatra and Java in the south to Mongolia and parts of southern Russia in the north. As one writer reminds us, over half the world’s population today lives in areas w:here Buddhism has at one time or another been the dominant religious influence. 1 Living Buddhism divides into ‘ three broad traditions: 2 I. The Theravada tradition of Sri Lanka and South-East Asia, also sometimes referred to as ‘southern’ Buddhism. Its canonical scriptures are preserved in Pali, an ancient Indian language closely related to Sanskrit. The school exemplifies a certain conservatism. Relative to the other two traditions, it can be regarded as generally closer in doctrine and practice to ancient Buddhism as it existed in the early centuries BCE in India. Today it is the religious tradition followed by a population of over IOO million in Sri Lanka, Burma, Thailand, Cambodia, and Laos. 2. The East Asian tradition of China, Korea, Japan, and Vietnam, also sometimes referred to as ‘eastern’ Buddhism. Its scriptures are preserved in Chinese and its general outlook is that of the Mahayana or ‘Great Vehicle’, a movement of ancient Indian Buddhist thought and practice that from about the beginning of the Christian era dubbed those who did not adopt its overall vision of Buddhism-represented today by the Theravada-followers of the ‘Lesser Vehicle’ (hinayiina). East Asian Buddhism is extremely diverse; it has coexisted with Confucianism, Taoism, 2 Introduction Shinto, and, more recently but less happily, Communism; it remains a significant religious tradition for a population of soo million to I,ooo million. 3· The Tibetan tradition, also sometimes referred to as ‘northern’ Buddhism. Its scriptures are preserved in Tibetan and once more its outlook is broadly that of the Mahayana, but its i:nore specific orientation is that of the ‘Vehicle of the Diamond Thunderbolt’ (vajra-yiina), also known as Tantric Buddhism, Today it is the religious tradition followed by IO million to 20 million, principally in Tibet and Mongolia, but also in parts of Nepal and Himalayan India. All three of these traditions look back to ancient Buddhism and the land of India, where Buddhism was born but whence it vir· tually disappeared over five centuries ago. The present volume was conceived as an introduction to Buddhist thought and practice, and is intended to be accessible to the reader with no previous knowledge of Buddhism. Given its great diversity and its long history, the task of introducing Buddhism is a daunting one. As is fashionable to point out these ·days, ‘Buddhism’ is something of an intellectual abstraction: in reality there is not one Buddhism but many Buddhisms. Any writer of an introductory text to Buddhism is faced with the problem of how to do justice to the richness and diversity of ~Buddhism both past and present. Most of the existing introductory volumes to Buddhism offer their readers some kind of general survey of the different ‘Buddhisms’, and attempt to give an equal and balanced treatment of all that Buddhism has been and still is. The advantage of this approach is that, ideally if not always in practice, it avoids the pitfall of seeming to imply that one or other form of Buddhism represents a ‘truer’ form of Buddhism than others, or that one has somehow captured the real essence of Buddhism. Its disadvantage is that, in a volume of some 300 pages, one is in danger of saying very little about an awful lot, and of presenting the reader with what amounts to a catalogue of dates, people, places, doctrines, and practices; a reader may finish such a book, yet somehow know very little of Buddhism. For this Introduction 3 reason it seems worth while trying to introduce Buddhism in a more explicitly focused way. The approach I have adopted in the present volume, then, is to try to identify and focus on those fundamental ideas a,nd practices that constitute something of a common heritage shared by the different traditions of Buddhism that exist in the world today. Of course, the precise nature of that common heritage is open to question. Nevertheless, the fact remains that the areas of Buddhist thought and practice outlined in the present volume -the story of the Buddha (Chapter 1), a textual and scriptural tradition (Chapter 2), the framework of the four noble truths (Chapter 3), the monastic and lay ways of life (Chapter 4), a cosmology based around karma and rebirth (Chapter 5), the teaching of no self and dependent arising (Chapter 6), a progressive path of practice leading on from good conduct. and devotions through stages of meditation to a higher understanding (Chapter 7), the theoretical systems of either the Abhidharma or the Madyamaka and Yogacara (Chapters 8 and 9), the path of the bodhisattva (Chapter 9)-are all, in one way or another, assumed by and known to all Buddhism. These are the foundations upon which Buddhism rests. Of course, I do not mean to suggest by this that a Buddhist layman in Tokyo and a Buddhist laywoman in Bangkok, that a monk in Colombo and a nun in Lhasa, would all respond to questions on these topics precisely along the lines set out in the relevant chapters below. None the less, it is not unreasonable nor, I think, is it to commit oneself to an essentialist view of Buddhism to suggest that, whatever the nature of the Buddhist terrain, one cannot dig much below the surface without coming across some trace of the patterns of thought and practice outlined here, even if at different times and in different places the constructions built on their foundations present their own distinctive and peculiar aspects. Moreover, the fact that those patterns of thought and practice are not immediately apparent does not of itself mean that they exert no influence. That we may not always be consciously aware of particular ideas and theories, or that we may be unable to articulate them in detail, does not 4 Introduction mean that those ideas fail to affect our view of the world. The principles of, say, Newtonian physics, Darwinian evolutionary theory, and Freudian psychology contribute to a world-viewthat is shared by many who have never read a word of what Newton, Darwin, or Freud wrote and would be hard pressed to explain in detail any of their ideas. I should, however, add that I have not entirely eschewed the general-survey approach; Chapter 9, on specifically Mahayana ideas, and especially Chapter IO, an overview of the history of the different traditions of Buddhism in Asia, are intended to give some indication of what I have not covered and provide some form of orientation for further study. Apart from its simply allowing a more sustained account of some significant aspects of Buddhist thought and practice, there is a further reason why I think focusing on the common heritage as indicated above is appropriate at the introductory level: it affords a perspective on the development of Buddhist thought and practice which calls into question what might be dubbed the standard ‘textbook’ view and is in fact more in tune with recent scholarship. This textbook view tends to see the history of Buddhism in terms of a division into two major ‘sects’: the Theravada and the Mahayana. More specifically, according to this ‘textbook’ view, in origin the Mahayana was at once a popular religious protest against the elitist monasticism of early Buddhism and a philosophical refutation of its dead-end scholasticism; moreover,this religious protest and philosophical refutation rapidly all but marginalized earlier forms of Buddhism. The research published in the last twenty years or so has increasingly made such a view of the development of Indian Buddhist thought and practice untenable. The Mahayana did not originate as a clearly defined ‘sect’ and, far from being a popular lay movement, it seems increasingly likely that.it began as a minority monastic movement and remained such for several hundred years, down to at least the fifth century CE. Moreover, what is becoming clearer is that many elements of Buddhist thought and practice that were once thought to be characteristic of the emerging Mahayana were simply developments within what has been called by some Introduction 5 ‘mainstream’ Buddhism;3 and while the Mahayana certainly criticized aspects of mainstream Buddhist thought and practice, much more was taken as said and done, and just carried over. Thus, instead of seeing Mahayana as simply superseding earlier forms of Buddhism in India, the approach adopted in the present volume is to try to focus on the common ground between the non-Mahayana and Mahayana in the formative phase of Indian Buddhist thought and practice, and by referring to both the Pali sources of Sri Lanka and the Sanskrit sources of northern India to present an outline of ‘mainstream’ Buddhist thought and practice as the foundations for developments in India and beyond. Such an approach, then, does tend to privilege what is ancient, but throughout· I have attempted to give some indication of how these basic principles of Buddhist thought and practice might relate to more recent developments. Let me add here a few words on my specific approach to my material. In describing Buddhist thought and practice, my aim has been, in the first place, simply to act as spokesman for its principles, and to try to articulate those principles as Buddhist tradition itself has understood them. In the second place, I have tried to give some indication of and pass some comment on the critical and scholarly issues that have emerged in the modern academic study of Buddhism over the last rso years or so. Some might question the need for yet another introductory volume on Buddhism, yet as a teacher of introductory courses on Buddhism at a university I find myself somewhat dissatisfied with the available teaching materials. Certainly there are available a number of survey-type books ranging from short and sketchy to more moderate-sized treatments. In addition there are some solid introductions to various aspects of Buddhism -the social history of Theravada, Mahayana thought, Chinese Buddhism, Tibetan Buddhism-but if one looks for a volume giving a more focused account, reflecting recent scholarship, of what, for want of a better expression, one might refer to as the principles of ‘mainstream’ Buddhist thought and practice, there appears to be a gap. It is hoped that the present work will go some way to filling that gap. 6 Introduction In sum, what distinguishes the present volume is that it contains rather more sustained expositions of Buddhist cosmology, no self and dependent arising, the path of meditation, and the theoretical Abhidharma framework (which underlies all later Buddhist thought) than other introductory books. Thus there is material here which, although basic from a Buddhist point of view, is only available in specialized books and articles. I hope, then, that while the book is intended to be accessible to the novice, there may also be something here for the elders of Buddhist studies. 1 The Buddha The Story of the Awakened One The historical Buddha In January 1898 an Englishman, W. C. Peppe, digging into a mound on his estate at Pipdihwa just the Indian side of the IndianNepalese border, unearthed a soapstone vase some six inches in height with a brief inscription around its lid. The inscription, written in the Brahmi script and dating from about the second century BCE, was in one of the ancient Indian dialects or Prakrits collectively referred to as Middle Indo-Aryan. The precise interpretation of the inscription remains problematic, but it appears to claim that the vase is ‘a receptacle of relics of the Blessed Buddha of the Sakyas’. 1 The circumstances of this find and the find itself actually reveal a considerable amount about the nature and long history of what we know today as ‘Buddhism’. Peppe was among the early excavators of ruined Buddhist stiipas or monumental burial mounds. Such stupas vary considerably in size. The largest were made to enshrine the relics of the Buddha himself or of Buddhist ‘saints’ or arhats (Pali arahat), while smaller ones contained the remains of more ordinary men and women. 2 Today countless stupas are to be found scattered across the Indian subcontinent (where over the past hundred years a few have been restored to something of their former glory) and also other countries where Buddhism spread. Buddhism was, then, in origin an Indian phenomenon. Beginning in the fifth century BCE, its teachings and institutions continued to flourish for some fifteen centuries on Indian soil, inspiring and moulding the intellectual, religious, and cultural life of India. During this period Buddhism spread via the old trade routes far beyond the 8 The Buddha confines of India right across Asia, from Afghanistan in the west to Japan in the east, affecting and touching the lives of millions of people. Yet by around the close of the twelfth century Bud” dhist institutions had all but disappeared from India proper, and it is in the countries and cultures that lie beyond India that Buddhism flourishes today. None the less all the variou~ living traditions of Buddhism in some way look back to and revere a figure who has a certain basis in history-a figure who lived and died in northern India several centuries before the beginning of the Christian era and belonged to a people known as the Sakyas (Pali Sakya). He is Sakya-muni, ‘the sage of the Sakyas’, or as our inscription prefers to call him buddho bhagavii-‘the Blessed Buddha’, ‘the Lord Buddha’. So who, and indeed what, was the Lord Buddha? This is a quesc tion that might be answered in a number of different ways, a question about which both the Buddhist tradition and the historian have something to say. The nature of the Buddha is a subject that the Buddhist tradition itself has expounded on at length and to which we will return below but, in brief, the word b_uddha is not a name but a title; its meaning is ‘one who has woken up’. This title is generally applied by the Buddhist tradition to a class of beings who are, from the perspective of ordinary humanity, extremely rare and quite extraordinary. In contrast to these Buddhas or ‘awakened ones’ the mass of humanity; along with the other creatures and beings that constitute the world, are asleep-asleep in the sense that they pass through their lives never knowing and seeing the world ‘as it is’ (yathii-bhutarrt). As a consequence they suffer. A buddha on the other hand awakens to the knowledge of the world as it truly is and in so doing finds release from suffering. Moreover-and this is perhaps the greatest significance of a buddha for the rest of humanity, and indeed for all the beings who make up the universe-a buddha teaches. He teaches out of sympathy and compassion for the suffering of beings, for the benefit and welfare of all beings; he teaches in order to lead others to awaken to the understanding that brings final relief from suffering. An ancient formula still used in Buddhist devotions today puts it as follows: The Buddha 9 For the following reasons he is a Blessed One: he is an Arhat, a perfectly and completely awakened one, perfect in his understanding and conduct, happy, one who understands the world, an unsurpassed trainer of unruly men, the teacher of both gods and men, a blessed buddha. 3 Such is a buddha in general terms, but what of the particular buddha with whom we started, whose relics appear to have been enshrined in a number of stupas across the north of India and to whom the Buddhist tradition looks as its particular founderthe historical Buddha? Let us for the moment consider the question not so much from the perspective of the Buddhist tradition as from the perspective of the historian. The Buddha and the Indian ‘renouacer’ tradition We can know very little of the historical Buddha with any degree of certainty. Yet within the bounds of reasonable historical probability we can form quite a clear picture of the kind of person the Buddha was and the main events of his life. The oldest Buddhist sources, which provide us with a number of details concerning the person and life of the Buddha, date from the fourth or third century BCE. Unfortunately when we tum to the nonBuddhist sources of a similar date, namely the earliest texts of the Jain and brahmanical traditions, there is no explicit mention of the Buddha at all. 4 It would be a mistake to conclude, however, that non-Buddhist sources thus provide us with no corroborative evidence for the picture of the Buddha painted in early Buddhist texts. Essentially the latter present the Buddha as a sramatJa (Pali samaf}a). This term means literally ‘one who strives’ and belongs to the technical vocabulary of Indian religion, referring as it does to ‘one who strives’ religiously or spiritually. It points towards a particular tradition that in one way or another has been of great significance in Indian religious history, be it Buddhist, Jain, or Hindu. Any quest for the historical Buddha must begin with the sramatJa tradition. Collectively our sources may not allow us to write the early history of this movement but they do enable us to say certain amount concerning its character. a IO The Buddha The tradition is sometimes called the ‘renouncer (sarrmyiisin) tradition’. What we are concerned with here is the phenomenon of individuals’ renouncing their normal role in society as a member of an extended ‘household’ in order to devote themselves to some form of religious or spiritual life. The ‘renouncer’ abandons conventional means of livelihood, such as farming or trade, and adopts instead the religious life as a means of livelihood. That is, he becomes a religious mendicant dependent on alms. What our sources make clear is that by the fifth century BCE this phenomenon was both widespread and varied. Thus while ‘renouncers’ had in common the fact .that they had ‘gone forth from the household life into homelessness’ (to use a phrase common in Buddhist sources), the kind of lifestyle they then adopted was not necessarily the same. This is suggested by some of the terms that we find in the texts: in addition to ‘one who strives’ and ‘renouncer’, we fil).d ‘wanderer’ (parivriijaka/paribbiijaka), ‘one who begs his share [of alms]’ (bhik(fulbhikkhu), ‘naked ascetic’ (ace/aka), ‘matted-hair ascetic’ (jatila), as well as a number of other terms. 5 Some of these wanderers and ascetics seem to have been loners, while others seem to have organized themselves into groups and lived under a teacher. Early renouncers seem to· have been for the most part male, although with the growth of Buddhism and Jainism it is certainly the case that women too began to be numbered among. their ranks. Three kinds of activity seem to have preoccupied these wanderers and. ascetics. First, there is the practice of austerities, such as going naked in all weathers, enduring all physical discomforts, fasting, or undertaking the vow to live like a cow or . even a dog. 6 Secondly, there is the cultivation of meditative and contemplative techniques aimed at producing what might, for the lack of a suitable technical term in English, be referred to as ‘altered states of consciousness’. In the technical vocabulary of Indian religious texts such states come to be termed ‘meditations’ (dhyiina/jhiina) or ‘concentrations’ (samiidhi); the attainment of such states of consciousness was generally regarded as bringing the practitioner to some deeper knowledge and experience of the nature of the world. Lastly there is the development of The Buddha II various philosophical views providing the intellectual justification for particular practices and the theoretical expression of the ‘knowledge’ to which they led. While some groups and individuals seem to have combined all three activities, others favoured one at the expense of the others, and the line between th’e practice of austerities and the practice of meditation may not always be clear: the practice of extreme austerity will certainly alter one’s state of mind. The existence of some of these different groups of ancient Indian wanderers and ascetics with their various practices and theories finds expression in Buddhist texts in a stock description of ‘six teachers of other schools’, who are each represented as expounding a particular teaching and practice. Another list, with no details of the associated teachings and practices, gives ten types of renouncer. In fact two other ancient Indian traditions that were subsequently of some importance in the religious life of India (the Ajivikas and the Jains) find a place in both these ancient Buddhist lists; the Jain tradition, of course, survives to this day. 7 But one of the most significant groups for the understanding of the religious milieu of the historical Buddha is omitted from these lists; this is the early brahmanical tradition. To explain who the ·brahmins (briihma1Ja) were requires a brief excursus into the early evolution of Indian culture and society. The brahmanical tradition It is generally thought that some time after the beginning of the second millennium BCE groups of a nomadic tribal people began to move south from ancient Iran, through the passes of the Hindu Kush and down into the plains of the Indus valley. These people spoke dialects of Old Indo-Aryan, that is, of Sanskrit and they are known as the Aryas. The Aryas who moved into India were descendants of nomadic pastoralists who had occupied the grasslands of central Asia, some of whom similarly moved west into Europe. Once in India the Aryas’ cultural influence gradually spread southwards and eastwards across the plains of northern India. By the time the Buddha was born, probably early in the fifth I2 The Buddha century BCE, the Aryas had been in India perhaps a thousand years and their cultural influence extended down the Ganges valley as far as Pataliputra (modern Patna). The coming of the Aryas into India did not bring political unity to northern India, but it did bring a certain ideology that constitutes one of the principal components of Indian culture. This Aryan vision of society was principally developed and articulated by a hereditary group within Aryan society known as briihmafJas or, in the Anglo-Indian spelling, brahmins. The original literature of the brahrnins is known as the Vedas, the oldest portions of which, found in the l_?.g Veda, date from about rsoo BCE. By the time of the Buddha, Vedic literature probably already comprised several different classes: the four collections (saf!lhitii) of verses attributed to the ancient seers (r#), the ritual manuals (also known as briihmaiJas) giving instruction in the carrying out of the elaborate Vedic sacrificial ritual, and ‘the forest books’ (iiraiJyaka) explaining the esoteric meaning of this sacrificial ritual. The final class of Vedic literature, the Upani~ads, containing further esoteric explanations of the sacrificial ritual, was still in the process of formation. Two aspects of the brahmanical vision are of particular importance, namely an understanding of society as reflecting a hierarchy of ritual ‘purity’, and a complex system of ritual and sacrifice. From the brahmanical perspective society comprises two groups: the Aryas and the non-Aryas. The former consists of the three hereditary classes (variJa) in descending order of purity: briihmaiJaS (whose prerogative and duty it is to teach and maintain the Vedic tradition), k~atriyas or rulers (whose prerogative and duty is to maintain order and where necessary inflict appropriate punishment), and the vaisyas (whose prerogative and duty is to generate wealth through farming and trade). These three classes are termed ‘twice born’ (dvija) by virtue of the fact that traditionally male members undergo an initiation (upanayana) into a period of study of the Vedic tradition under the supervision of a brahmin teacher; at the end of this period of study it is their duty to maintain the household sacrificial fires and, with the help ofbrahmins, carry out various sacrificial rituals in accordance with the prescriptions of Vedic tradition. The non-Aryas The Buddha 13 make up the fourth class, the sildras or servants, whose basic duty it is to serve the three other classes. While it is important not to confuse these four classes (varlJa) and the countless castes (jiiti) oflater Indian society, it is none the less the ideology of the relative ritual purity of the classes that underpins the medieval and .modern Indian ‘caste system’. The brahmins’ hereditary ritual status empowered them to carry out certain ritual functions that members of other classes were excluded from, but at the time of the Buddha not all brahmins were full-time ‘priests’. Precisely how brahmins related to the various groups of wandering ascetics is not clear. 8 In part we can see the brahmanical vision of society and that of the wandering ascetics as opposed to each other, in part we can see the two as complementing each other. To accept the brahmanical view of the world was to accept brahmanical authority as an aspect of the eternal structure of the universe and, as such, unassailable. Yet wandering ascetics threatened brahmanical supremacy by offering rival visions of the world and society. On the other hand, within brahmanical circles we find the development of certain esoteric theories of the nature of the sacrificial ritual and philosophical views about the ultimate nature of man and his relationship to the universe at large. These theories may to some extent have drawn on ideas developing amongst the groups of wandering ascetics; at the same time they may have substantially contributed to the development of the tradition of the wanderers itself, since it is clear that brahmin circles were an important recruiting ground for the various groups of wandering ascetics. Yet it seems clear that in certain respects the Buddhajs teachings were formulated as a response to certaih brahmanical teachings. 9 The Buddha and history It is in this milieu that the historian must understand the historical Buddha as existing. And given this milieu, the bare ‘facts’ of the Buddha’s life as presented by tradition are historically unproblematic and inconsequential. The precise dates of the Buddha’s life are uncertain. A widespread Buddhist tradition records that he was in his eightieth r4 The Buddha year when he died, and the dates for his life most widely quoted in modern published works are 566-486 BCE. These dates are arrived at by, first, following a tradition, recorded in the Pali sources of ‘southern’ Buddhism, that the great Mauryan king, Asoka, was consecrated 2r8 years after the death of the Buddha, and, secondly, taking 268 BCE as the year of Asoka’s accession. This is done on the basis of the Asokan rock-edict reference to rulers in the wider Hellenic world who can be dated from other ancient sources. But both the figure 2r8 and the accession of Asoka in 268 BCE are problematic. In contrast to the southern ‘long chronology’, northern Buddhist Sanskrit sources. adopt a ‘short chronology’, placing Asoka’s accession just roo years after the death of the Buddha, while recent research suggests that Asoka’s accession may be plausibly placed anywhere between 280 and 267 BCE. 10 But such figures as 2 r8 and roo should properly be seen as ideal round numbers.U Moreover, as was first pointed out by Rhys Davids and more recently by Richard Gombrich, a time lapse of rather less than 2r8 years from the Buddha’s death to Asoka’s accession is suggested by the figures associated with the lineage of teachers found in a Pali source, namely an ancient Sri Lankan chronicle, the DipavaJ!lsa. 12 While there is no scholarly consensus on the precise dates of the Buddha, a detailed examination of all the available data and arguments by scholars in recent years has resulted in a general tendency to bring the date of the Buddha considerably forward and pl&ce his death much nearer 400 BCE than 500 BCE. . The earliest Buddhist sources state that the future Buddha was born Siddhartha Gautama (Pali Siddhattha Gotama), the son of a local chieftain-a riijan-in Kapilavastu (Pali Kapilavatthu) on what is now the Indian-Nepalese border. He was thus a member of a relatively privileged and wealthy family, and enjoyed a comfortable upbringing. While the later Buddhist tradition, in recounting the story of his youth, certainly likes to dwell on the wealth of Siddhartha’s family and the extravagance of his princely upbringing, there is something of a cultural misunderstanding involved in the notion that the Buddhist tradition presents the Buddha as born a royal prince, the son of a great king. The Buddha IS In representing the Buddha as a rajan or k$atriya the tradition is effectively recording little more than that he was, in European cultural terms, a member of a locally important aristocratic family. At some point he became disillusioned with his comfortable and privileged life; he became troubled by a sense of the suffering that, in the form of sickness, old age, and death, sooner or later awaited him and everyone else. In the face of this, the pleasures he enjoyed seemed empty and of little value. So he left home and adopted the life of a wandering ascetic, a srama!Ja, to embark on a religious and spiritual quest. He took instruction from various teachers; he practised extreme austerities as was the custom of some ascetics. Still he was not satisfied. Finally, seated in meditation beneath an asvattha tree on the banks of the Nairafijana in what is now the north Indian state of Bihar, he had an experience which affected him profoundly, convincing him that he had come to the end of his quest. While the historian can make no judgement on the nature of this experience, the Buddhist tradition (apparently bearing witness to the Buddha’s own understanding of his experience) calls it bodhi or ‘awakening’ and characterizes it as involving the deepest understanding of the nature of suffering, its cause, its cessation, and the way leading to its cessation. The Buddha devoted the rest of . his life to teaching this ‘way to the cessation of suffering’ to groups of wanderers and ordinary householders. In the course of his wanderings across the plains that flank the banks of the Ganges he gathered a considerable following and by the time of his death at about the age of So he had established a well-organized mendicant community which attracted considerable support from the wider population. His followers cremated his body and divided up the relics which were enshrined in a number of stupas which became revered shrines. That the subsequent Buddhist tradition is founded upon and inspired by the teaching activity of a charismatic individual who lived some centuries before the beginning of the Christian era can hardly be doubted. In the words of the great Belgian scholar Etienne Lamotte, ‘Buddhism cannot be explained unless we accept that it has its origin in the strong personality of its 16 The Buddha founder.’ 13 Given this premiss, none of the bare details of the Buddha’s life is particularly problematic for the historiansomething we should bear in mind in the face of certain modern scholarly discussions of the life of the Buddha, such as Andre Bareau’s, which, in dwelling on t.he absence of corroborative evidence for many of the details of the traditional life of the Buddha, introduces a note of undue scepticism with regard to the whole account. Of course, as the Buddhist tradition tells it, the story of the life of the Buddha is not history nor meant to be. The whole story takes on a mythic and legendary character. A wealth of detail is brought in capable of being read metaphorically, allegorically, typologically, and symbolically. Much of this detail is to modern sensibilities of a decidedly ‘miraculous’ and ‘supernatural’ kind. The story of the Buddha’s life becomes not an account of the particular and individual circumstances of a man who, some 2,500 years ago, left home to become a wandering ascetic, but something universal, an archetype; it is the story of all those who have become buddhas in the past and all who will become buddhas in the future, and, in a sense, of all who follow the Buddhist path. It is the story of the Buddhist path, a story that shows the way to a profound religious truth. Yet for all that, many of the details of his eady life given in the oldest sources remain evocative of some memory of events from a distant time. If we persist in distinguishing and holding apart myth and history, we are in danger of missing the story’s own sense of truth. Furthermore, the historian must recognize that he has virtually no strictly historical criteria for distinguishing between history and myth in the accounts of the life of the Buddha. And at that point he should perhaps remain silent and let the story speak for itself. 14 The legend of the Buddha Sources The centrepiece of the legend of the Buddha is the story of the Buddha’s life from his conception to the events of his awakening and his first teaching. This narrative must be accounted one The Buddha I7 of the great stories of the world. Part of the common heritage of Buddhism, it is known throughout Asia wherever Buddhism has taken root. The core of this story and not a few of its details are already found in the Sutra and Vinaya collections of early Buddhist texts (see next chapter). 15 In literary works ‘and in sculptural reliefs that date from two or three centuries later, we find these details embellished and woven together to form a more sustained narrative. The classical literary tellings of the story are found in Sanskrit texts such as the Mahiivastu (‘Great Story’, first century cE), the Lalitavistara (‘Graceful Description’, first century cE), in Asvagho~a’s poem the Buddhacarita (‘Acts of the Buddha’, second century cE), and in the Pali Nidiinakathii (‘Introductory Tale’, second or third century CE), which forms an introduction to the commentary on the Jiitaka, a collection of stories of the Buddha’s previous births. 16 New narratives of the life of the Buddha have continued to be produced down to modern timesP Tibetan tradition structures the story of the Buddha’s life around twelve acts performed by all buddhas, while Theravadin sources draw up a rather longer list of thirty features that are the rule (dhammatii) for the lives of all buddhas. 18 The substance of these two lists is already found in the oldest tellings of the story. What follows is in effect the story of these twelve acts and (most of) the thirty features, told with a bias to how they are recounted in the early discourses of the Buddha and Pali sources, together with some comments aimed at providing a historical perspective on the development of the story. The legend The Buddhist and general Indian world-view is that all sentient beings are subject to rebirth: all beings are born, live, die, and are reborn again and again in a variety of different circumstances. This process knows no definite beginning and, ordinarily, no definite end. The being who becomes a buddha, like any other being, has known countless previous lives-as a human being, an animal, and a god. An old tradition tells us that the life before the one in which the state of buddhahood is reached is always 18 The Buddha spent as a ‘god’ (deva) in the heaven of the Contented (Tu~ita/ Tusita). Here the bodhisattva (Pali bodhisatta)-the being intent on awakening-dwells awaiting the appropriate time to take a human birth and become a buddha. Dwelling in the Tu~ita heaven is the first of the twelve acts, but how does the bodhisattva come to be dwelling here? The answer, in short, is that it is as a result of having practised ‘the perfections’ (piiramitii/piiraml) over many, many lifetimes. Long ago, in fact incalculable numbers of aeons ago, there lived an ascetic called Sumedha (or Megha by some) who encountered a former buddha, the Buddha DipaQlkara. This meeting affected Sumedha in such a way that he too aspired to becoming a buddha. What impressed Sumedha was DipaQlkara’s very presence and a sense of his infinite wisdom and compassion, such that he resolved that he would do whatever was necessary to cultivate and perfect these qualities in himself. Sumedha thus set out on the path of the cultivation of the ten ‘perfections’: generosity, morality, desirelessness, vigour, wisdom, patience, truthfulness, resolve, loving kindness, and equanimity. In undertaking the cultivation of these perfections Sumedha became a bodhisattva, a being intent on and destined for buddhahood, and it is the life in which he becomes the Buddha Gautama some time in the fifth century BCE that represents the fruition of that distant aspiration. Many jiitakas-‘[tales] of the [previous] births [of the Bodhisattva]’-recount how the Bodhisattva gradually developed the ‘perfections’. Such stories, like the story of the Buddha’s life, are deeply embedded in Buddhist culture and serve to emphasize how, for the Buddhist, the being who dwells in Tu~ita as one intent on buddhahood is a being of the profoundest spiritual qualities. The appearance of such a being in the world may not be unique, but is nevertheless a rare and special circumstance, for a buddha only appears in the world when the teachings of a previous buddha have been lost and when beings will be receptive to his message. So it is said that surveying the world from Tu~ita the ·Bodhisattva saw that the time had come for him to take a human birth and at last become a buddha; he saw that the ‘Middle Coun- The Buddha 19 try’ of the great continent of Jambudvipa (India) was the place in which to take birth, for its inhabitants would be receptive to his message. The Bodhisattva was conceived on the full moon night of A~a
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Chapter 3 Bacteria and Archaea ©McGraw-Hill Education Form and Function of Bacteria and Archaea How bacteria and archaea are different from eukaryotes: • The way their DNA is packaged: lack of nucleus and histones • The makeup of their cell wall: peptidoglycan and other unique chemicals • Their internal structures: lack of membrane-bound organelles ©McGraw-Hill Education The Structure of the Bacterial Cell All bacterial cells possess: • Cytoplasmic membrane • Cytoplasm • Ribosomes • Cytoskeleton • One (or a few) chromosome(s) Most bacterial cells possess: • Cell wall • A surface coating called a glycocalyx ©McGraw-Hill Education Structures Found in Some Bacteria Some, but not all bacterial cells possess: • Flagella, pili, and fimbriae • An outer membrane • Nanowires/nanotubes • Plasmids • Inclusions • Endospores • Microcompartments ©McGraw-Hill Education Structure of a Bacterial Cell Jump to long description ©McGraw-Hill Education Bacterial Shapes and Arrangements Most bacteria function as independent singlecelled, unicellular organisms: • Some act as a group in colonies or biofilms • Some communicate through nanotubes Bacteria have an average size of 1 μm (micron): • Cocci: circumference of 1 μm • Rods: length of 2 μm and a width of 1 μm Pleomorphism: variation in the size and shape of cells of a single species due to nutritional and genetic differences ©McGraw-Hill Education Bacterial Shapes Jump to long description ©McGraw-Hill Education Source: CDC/Janice Haney Carr (a); Source: CDC/Janice Haney Carr (b); Source: CDC/Janice Haney Carr (c); Source: USDA/Photo by De Wood. Digital colorization by Chris Pooley (d); ©VEM/Science Source (e); ©Eye of Science/Science Source (f) Bacterial Arrangements: Cocci Arrangement of cocci: • Single • Diplococci: pairs • Tetrads: groups of four • Staphylococci or micrococci: irregular clusters • Streptococci: chains • Sarcina: cubical packet of eight, sixteen, or more cells ©McGraw-Hill Education Arrangement of Cocci Jump to long description ©McGraw-Hill Education Bacterial Arrangements: Bacilli Arrangement of bacilli: • Single • Diplobacilli: pair of cells with ends attached • Streptobacilli: chain of several cells ©McGraw-Hill Education ©De Agostini/Getty Images External Structures Appendages: • Motility: flagella and axial filaments • Attachment points or channels: fimbriae, pili, and nanotubes/nanowires Flagellum: • Primary function is motility • Three distinct parts: • Filament • Hook • Basal body ©McGraw-Hill Education Flagellum of a Gram-Negative Cell Jump to long description ©McGraw-Hill Education Sarkar MK1, Paul K, Blair D., “Chemotaxis signaling protein CheY binds to the rotor protein FliN to control the direction of flagellar rotation in Escherichia coli,” PNAS May 18, 2010 vol. 107 no. 20 9370-9375 (b) Arrangement of Flagella Polar arrangement: flagella attached at one or both ends of the cell • Monotrichous: single flagellum • Lophotrichous: small bunches or tufts of flagella emerging from the same site • Amphitrichous: flagella at both poles of the cell Peritrichous arrangement: flagella are dispersed randomly over the surface of the cell ©McGraw-Hill Education Types of Flagellar Arrangements Jump to long description ©McGraw-Hill Education ©Science Photo Library/Alamy Stock Photo (a); Source: CDC/ Melissa Brower (b); ©Heather Davies/Science Source (c); ©Smith Collection/Gado/Getty Images (d) Fine Points of Flagellar Function Chemotaxis: movement of bacteria in response to chemical signals: • Positive chemotaxis: movement toward favorable chemical stimulus • Negative chemotaxis: movement away from a repellant • Run: rotation of flagellum counterclockwise, resulting in a smooth linear direction • Tumble: reversal of the direction of the flagellum, causing the cell to stop and change course ©McGraw-Hill Education Operation of Flagella Jump to long description ©McGraw-Hill Education Chemotaxis in Bacteria Jump to long description ©McGraw-Hill Education Periplasmic Flagella Spirochetes: corkscrew-shaped bacteria: • Possess an unusual, wriggly mode of locomotion due to periplasmic flagella Periplasmic flagella: • Also called axial filaments • Internal flagellum enclosed in the space between the cell wall and the cytoplasmic membrane ©McGraw-Hill Education Appendages for Attachment or Channel Formation: Fimbriae Fimbria/fimbriae: • Small, bristle-like fibers sprouting off the surface of many bacterial cells • Allow tight adhesion between fimbriae and epithelial cells, allowing bacteria to colonize and infect host tissues ©McGraw-Hill Education ©Eye of Science/Science Source Appendages for Attachment or Channel Formation: Pili and Nanotubes Pilus/pili: • Used in conjugation between bacterial cells • Well characterized in gram-negative bacteria • Type IV pilus can transfer genetic material, act like fimbriae and assist in attachment, and act like flagella and make a bacterium motile ©McGraw-Hill Education Conjugating Process ©McGraw-Hill Education ©L. Caro/SPL/Science Source S Layer and Glycocalyx S layer: • Single layers of thousands of copies of a single protein linked together like chain mail • Only produced when bacteria are in a hostile environment Glycocalyx: • Coating of repeating polysaccharide or glycoprotein units • Slime layer: loose, protects against loss of water and nutrients • Capsule: more tightly bound, denser, and thicker; produce a sticky (mucoid) character to colonies on agar ©McGraw-Hill Education Position of Bacterial S Layer ©McGraw-Hill Education ©Russell Kightley/Science Source Encapsulated Bacteria ©McGraw-Hill Education CDC (a); ©Michael Abbey/Science Source (b) Specialized Functions of the Glycocalyx Capsules: • Formed by many pathogenic bacteria • Have greater pathogenicity • Protect against phagocytosis Biofilms: • Plaque on teeth protects bacteria from becoming dislodged • Responsible for persistent colonization of plastic catheters, IUDs, metal pacemakers, and other implanted medical devices ©McGraw-Hill Education Biofilm Formation Jump to long description ©McGraw-Hill Education ©Scimat/Science Source (b) The Cell Envelope Lies outside the cytoplasm Composed of two or three basic layers that each perform a distinct function, but together act as a single protective unit: • Cell wall • Cytoplasmic membrane • Outer membrane (in some bacteria) ©McGraw-Hill Education Comparison of Gram-Positive and Gram-Negative Cell Envelopes Jump to long description ©McGraw-Hill Education ©Dr. Kari Lounatmaa/Science Source (gram-positive cell.); ©Dennis Kunkel Microscopy, Inc./Medical Images (gram-negative cell) The Cell Wall Helps determine the shape of a bacterium Provides strong structural support to keep the bacterium from bursting or collapsing because of changes in osmotic pressure: • Certain drugs target the cell wall, disrupting its integrity and causing cell lysis (disintegration or rupture) of the cell Gains its relative rigidity from peptidoglycan ©McGraw-Hill Education Peptidoglycan Compound composed of a repeating framework of long glycan (sugar) chains cross-linked by short peptide (protein) fragments Provides a strong but flexible support framework Jump to long description ©McGraw-Hill Education Gram-Positive Cell Wall Thick, homogenous sheet of peptidoglycan: • 20 to 80 nm in thickness Contains teichoic acid and lipoteichoic acid: • Function in cell wall maintenance and enlargement • Contribute to the acidic charge on the cell surface ©McGraw-Hill Education Gram-Negative Cell Wall Single, thin sheet of peptidoglycan: • 1 to 3 nm in thickness Thinness gives gram-negative cells greater flexibility and sensitivity to lysis ©McGraw-Hill Education Steps in a Gram Stain Jump to long description ©McGraw-Hill Education ©McGraw-Hill Education Nontypical Cell Walls: Acid-Fast Bacteria Mycobacterium and Norcardia: contain peptidoglycan and stain gram-positive, but bulk of cell wall is composed of unique lipids Mycolic acid: • Very-long-chain fatty acid • Found in the cell walls of acid-fast bacteria • Contributes to the pathogenicity of the bacteria • Makes bacteria highly resistant to certain chemicals and dyes ©McGraw-Hill Education Nontypical Cell Walls: Archaea Some have cell walls composed entirely of polysaccharides Others have cell walls made of pure protein All lack true peptidoglycan structure Some lack a cell wall entirely ©McGraw-Hill Education Mycoplasmas and Other Cell-Wall-Deficient Bacteria Mycoplasmas: • Naturally lack a cell wall • Sterols in the cell membrane stabilize the cell against lysis • Mycoplasma pneumoniae: “walking pneumonia” L forms: • Some bacteria that naturally have a cell wall but lose it during part of their life cycle • Role in persistent infections • Resistant to antibiotics ©McGraw-Hill Education The Gram-Negative Outer Membrane Similar in composition to most membranes, except it contains specialized polysaccharides and proteins Lipopolysaccharide: • Signaling molecules and receptors • Endotoxin Porin proteins: • Special membrane channels that only allow certain chemicals to penetrate ©McGraw-Hill Education Cytoplasmic Membrane Structure A lipid bilayer with proteins embedded Regulates transport of nutrients and wastes Selectively permeable: special carrier mechanisms for passage of most molecules ©McGraw-Hill Education Differences in Cell Envelope Structure Outer membrane of gram-negative bacteria contributes an extra barrier: • Resistant to certain antimicrobial chemicals • More difficult to inhibit or kill than gram-positive bacteria Alcohol-based compounds dissolve lipids in the outer membrane and therefore damage the cell: • Alcohol swabs used to cleanse the skin before certain medical procedures Treatment of infections caused by gram-negative bacteria requires drugs that can cross the outer membrane ©McGraw-Hill Education The Cytoplasm 70 to 80% water Complex mixture of sugars, amino acids, and salts Serves as a pool for building blocks for cell synthesis or sources of energy ©McGraw-Hill Education Bacterial Chromosomes and Plasmids The hereditary material of most bacteria exists in the bacterial chromosome DNA is aggregated in the nucleoid Plasmids: • Nonessential pieces of DNA • Confer protective traits such as drug resistance and toxin and enzyme production ©McGraw-Hill Education Ribosomes Site of protein synthesis ©McGraw-Hill Education Bacterial Ribosome Jump to long description ©McGraw-Hill Education Inclusion Bodies and Microcompartments Used for food storage Pack gas into vesicles for buoyancy Store crystals of iron oxide with magnetic properties Bacterial microcompartments: • Outer shells made of protein, arranged geometrically • Packed full of enzymes designed to work together in biochemical pathways ©McGraw-Hill Education The Cytoskeleton Some bacteria produce long polymers of protein similar to eukaryotic cells for the cytoskeleton: • Arranged in helical ribbons around the cell • Contribute to cell shape • Have also been identified in archaea • Unique to non-eukaryotic cells – may be a potential target for antibiotic development ©McGraw-Hill Education Bacterial Endospores Dormant bodies Produced by Bacillus, Clostridia, and Sporosarcina Vegetative cell: metabolically active Sporulation: induced by environmental conditions Endospores resist extremes of heat, drying, freezing, radiation, and chemicals that would kill vegetative cells ©McGraw-Hill Education ©Science Source Sporulation Process in Bacillus Species Jump to long description ©McGraw-Hill Education ©Science Source The Medical Significance of Bacterial Endospores Bacillus anthracis: agent of anthrax Clostridium tetani: cause of tetanus Clostridium perfringens: cause of gas gangrene Clostridium botulinum: cause of botulism Clostridium difficile: “C. diff,” a serious gastrointestinal disease ©McGraw-Hill Education Archaea: The Other “Prokaryotes” Considered a third cell type in a separate superkingdom More closely related to domain Eukarya than bacteria: • Share rRNA sequences not found in bacteria • Protein synthesis and ribosomal subunit structures are similar ©McGraw-Hill Education Archaea Differ from Other Cell Types Extremophiles: • Some live at extremely high or low temperatures • Some need extremely high salt or acid concentrations to survive • Some live on sulfur or methane Some live on the human body and may be capable of causing human disease ©McGraw-Hill Education Comparison of Three Cellular Domains Characteristic Bacteria Chromosomes Single or a few, circular Single, circular Types of ribosomes 70S 70S but structure is similar to 80S 80S Contains unique ribosomal RNA signature sequences + + + Eukarya(-like) protein synthesis − + + Cell wall made of peptidoglycan + − − Cytoplasmic membrane lipids Fatty acids with ester linkages Long-chain, branched hydrocarbons with ether linkages Fatty acids with ester linkages Sterols in membrane − (some exceptions) − + Nucleus and membrane-bound organelles No No Yes Flagellum Bacterial flagellum Archaellum Eukaryotic flagellum ©McGraw-Hill Education Archaea Eukarya Multiple, linear Chapter 5 Viral Structure and Multiplication ©McGraw-Hill Education The Position of Viruses in the Biological Spectrum Viruses infect every type of cell, including bacteria, algae, fungi, protozoa, plants, and animals Seawater can contain 10 million viruses per milliliter For many years, the cause of viral infections was unknown: • Louis Pasteur hypothesized that rabies was caused by a “living thing” smaller than bacteria • He also proposed the term virus, which is Latin for “poison” ©McGraw-Hill Education The Viral Debate Two sides of the debate: • Since viruses are unable to multiply independently from the host cell, they are not living things and should be called infectious molecules • Even though viruses do not exhibit most of the life processes of cells, they can direct them, and thus are certainly more than inert and lifeless molecules Viruses are better described as active or inactive rather than alive or dead ©McGraw-Hill Education The Vital Role of Viruses in Evolution Infect cells and influence their genetic makeup Shape the way cells, tissues, bacteria, plants, and animals have evolved 8% of the human genome consists of sequences that come from viruses 10 to 20% of bacterial DNA contains viral sequences Obligate intracellular parasites: • Cannot multiply unless they invade a specific host cell and instruct its genetic and metabolic machinery to make and release new viruses ©McGraw-Hill Education Properties of Viruses (1) Are obligate intracellular parasites of bacteria, protozoa, fungi, algae, plants, and animals Are ultramicroscopic in size, ranging from 20 nm up to 1,000 nm (diameter) Are not cells; structure is very compact and economical Do not independently fulfill the characteristics of life Basic structure consists of protein shell (capsid) surrounding nucleic acid core ©McGraw-Hill Education Properties of Viruses (2) Nucleic acid can be either DNA or RNA, but not both Nucleic acids can be double-stranded DNA, single-stranded DNA, single-stranded RNA, or double-stranded RNA Molecules on virus surfaces give them high specificity for attachment to host cell Multiply by taking control of host cell’s genetic material and regulating the synthesis and assembly of new viruses Lack enzymes for most metabolic processes Lack machinery for synthesizing proteins ©McGraw-Hill Education How Viruses Are Classified and Named For many years, animal viruses were classified on the basis of their hosts and the diseases they caused Newer classification systems emphasize the following: • Hosts and diseases they cause • Structure • Chemical composition • Similarities in genetic makeup ©McGraw-Hill Education Virus Size Range Smallest infectious agents Smallest viruses: parvoviruses around 20 nm in diameter Largest viruses: herpes simplex virus around 150 nm in length Some cylindrical viruses can be relatively long (800 nm) but are so narrow in diameter (15 nm) that their visibility is limited without an electron microscope ©McGraw-Hill Education Size Comparison of Viruses with a Eukaryotic Cell (Yeast) and Bacteria Jump to long description ©McGraw-Hill Education Viral Architecture Is Best Observed with Special Stains and Electron Microscopy Jump to long description ©McGraw-Hill Education Source: CDCl/Dr. F. A. Murphy (a); ©Phototake (b); ©A.B. Dowsette/SPL/Science Source (c) Viral Components (1) Viruses bear no resemblance to cells and lack any of the protein-synthesizing machinery found in cells Viral structure is composed of regular, repeating subunits that give rise to their crystalline appearance The structure contains only those parts needed to invade and control a host cell: • External coating • Core containing one or more nucleic acid strains of DNA or RNA • Sometimes one or two enzymes ©McGraw-Hill Education Viral Components (2) Capsid: protein shell that surrounds the nucleic acid: • Nucleocapsid: the capsid together with the nucleic acid • Naked viruses consist only of a nucleocapsid. Envelope: external covering of a capsid, usually a modified piece of the host’s cell membrane Spikes can be found on naked or enveloped viruses: • Project from the nucleocapsid or the envelope • Allow viruses to dock with host cells Virion: a fully formed virus that is able to establish an infection in a host cell ©McGraw-Hill Education Structure of Viruses Jump to long description ©McGraw-Hill Education Viral Capsid Capsid: • Most prominent feature of viruses • Constructed from identical protein subunits called capsomeres • Capsomeres spontaneously self-assemble into the finished capsid Two different types: • Helical • Icosahedral ©McGraw-Hill Education Viral Envelope Enveloped viruses: • Take a bit of the cell membrane when they are released from a host cell Enveloped viruses can bud from: • Cell membrane • Nuclear envelope • Endoplasmic reticulum More flexible than the capsid so enveloped viruses are pleomorphic ©McGraw-Hill Education Helical Capsid Structure Helical Capsids Naked Enveloped The simpler helical capsids have rod-shaped capsomeres that bond together to form a series of hollow discs resembling a bracelet. During the formation of the nucleocapsid, these discs link with other discs to form a continuous helix into which the nucleic acid strand is coiled. The nucleocapsids of naked helical viruses are very rigid and tightly wound into a cylinder-shaped package. An example is the tobacco mosaic virus, which attacks tobacco leaves. Enveloped helical nucleocapsids are more flexible and tend to be arranged as a looser helix within the envelope. This type of morphology is found in several enveloped human viruses, including influenza, measles, and rabies. Naked Capsids ©McGraw-Hill Education Enveloped Capsids ©Science Source, Source: CDC/Dr. Fred Murphy Icosahedral Capsid Structure Icosahedral Capsids These capsids form an icosahedron (eye″-koh-suh-hee′-drun)—a threedimensional, 20-sided figure with 12 evenly spaced corners. The arrangements of the capsomeres vary from one virus to another. Some viruses construct the capsid from a single type of capsomere, while others may contain several types of capsomeres. There are major variations in the number of capsomeres; for example, a poliovirus has 32, and an adenovirus has 252 capsomeres. Naked Adenovirus is an example of a naked icosahedral virus. In the photo you can clearly see the spikes, some of which have broken off. Enveloped Two very common viruses, hepatitis B virus and the herpes simplex virus, possess enveloped icosahedrons. Naked Capsids ©McGraw-Hill Education Enveloped Capsids ©Dr. Linda M. Stannard, University of Cape Town/Science Source, ©Dr. Linda M. Stannard, University of Cape Town/Science Source (hep B virus); ©Eye of Science/Science Source Complex Capsid Structure Complex Capsids ©McGraw-Hill Education Complex capsids, only found in the viruses that infect bacteria, may have multiple types of proteins and take shapes that are not symmetrical. They are never enveloped. The one pictured on the right is a T4 bacteriophage. ©AmiImages/Science Source Nucleic Acids: At the Core of a Virus Genome: the sum total of the genetic information carried by an organism Viruses contain DNA or RNA, but not both The number of viral genes is quite small compared with that of a cell: • Four genes in hepatitis B virus • Hundreds of genes in some herpesviruses • Possess only the genes needed to invade host cells and redirect their activity ©McGraw-Hill Education Variety in Viral Nucleic Acid DNA viruses: Single-stranded (ss) or double-stranded (ds; linear or circular) RNA viruses: can be double-stranded, but more often single-stranded: • Positive-sense RNA: ready for immediate translation • Negative-sense RNA: must be converted before translation can occur • Segmented: individual genes exist on separate pieces of RNA • Retroviruses: carry their own enzymes to create DNA out of their RNA ©McGraw-Hill Education Viral Nucleic Acid Virus Name Disease It Causes Variola virus Smallpox Herpes simplex II Genital herpes Parvovirus Erythema infectiosum (skin condition) DNA Viruses Examples Double-stranded DNA Single-stranded DNA RNA Viruses–Examples Single-stranded (+) sense Poliovirus Poliomyelitis Single-stranded (−) sense Influenza virus Influenza Double-stranded RNA Rotavirus Gastroenteritis Single-stranded RNA + reverse transcriptase HIV AIDS ©McGraw-Hill Education Other Substances in the Virus Particle Enzymes for specific operations within their host cell: • Polymerases that synthesize DNA and RNA • Replicases that copy RNA • Reverse transcriptase synthesizes DNA from RNA Completely lack the genes for synthesis of metabolic enzymes Some viruses carry away substances from their host cell: • Arenaviruses pack along host ribosomes • Retroviruses borrow the host’s tRNA molecules ©McGraw-Hill Education Lytic Replication Cycle in Animal Viruses General phases of the animal lytic viral replication cycle: • Adsorption(Attachment) • Penetration • Uncoating • Synthesis • Assembly • Release The length of the replication cycle varies from 8 hours in polioviruses to 36 hours in herpesviruses ©McGraw-Hill Education Adsorption(Attachment) A virus can invade its host cell only through making an exact fit with a specific host molecule Host range: the limited range of cells that a virus can infect: • Hepatitis B: liver cells of humans • Poliovirus: intestinal and nerve cells of primates • Rabies: various cells of all mammals Cells that lack compatible virus receptors are resistant to adsorption and invasion by that virus Tropisms: specificities of viruses for certain tissues ©McGraw-Hill Education Viral Attachment Process Jump to long description ©McGraw-Hill Education Penetration and Uncoating The flexible cell membrane of the host is penetrated by the whole virus or its nucleic acid Penetration through endocytosis happens when an entire virus is engulfed by the cell and enclosed in a vacuole or vesicle Direct fusion of the viral envelope with the host cell membrane: • Envelope merges directly with the cell membrane, liberating the nucleocapsid into the cell’s interior ©McGraw-Hill Education Penetration by Animal Viruses Jump to long description ©McGraw-Hill Education Synthesis: Replication and Protein Production DNA viruses: • Enter the host cell’s nucleus and are replicated and assembled there RNA viruses: • Replicated and assembled in the cytoplasm Retroviruses turn their RNA genomes into DNA ©McGraw-Hill Education Assembly and Release Assembly: virus is put together using “parts” manufactured during the synthesis process Release: the number of viruses released by infected cells is variable, controlled by: • Size of the virus • Health of the host cell Poxvirus-infected cell: 3,000 to 4,000 virions Poliovirus-infected cell: 100,000 virions Immense potential for rapid viral proliferation ©McGraw-Hill Education Maturation and Release of Enveloped Viruses ©McGraw-Hill Education ©Chris Bjornberg/Science Source (b) Lytic Cycle of Animal Viruses (1) 1. Adsorption(Attachment) • The virus encounters a susceptible host cell and adsorbs specifically to receptor sites on the cell membrane • The membrane receptors that viruses attach to are usually proteins that the cell requires for its normal function • Glycoprotein spikes on the envelope (or on the capsid of naked viruses) bind to the cell membrane receptors 2. Penetration and Uncoating • In this example, the entire virus is engulfed (endocytosed) by the cell and enclosed in a vacuole or vesicle • When enzymes in the vacuole dissolve the envelope and capsid, the virus is said to be uncoated, a process that releases the viral nucleic acid into the cytoplasm ©McGraw-Hill Education Life Cycle of Animal Viruses (2) 3. Synthesis: Replication and Protein Production • Viral nucleic acid begins to synthesize the building blocks for new viruses • Some viruses come equipped with the necessary enzymes for synthesis of viral components; others utilize those of the host • Proteins for the capsid, spikes, and viral enzymes are synthesized on the host’s ribosomes using its amino acids ©McGraw-Hill Education Life Cycle of Animal Viruses (3) 4. Assembly • Mature virus particles are constructed from the growing pool of parts • Capsid is first laid down as an empty shell that will serve as a receptacle for the nucleic acid strand • Viral spikes are inserted into the host’s cell membrane so they can be picked up as the virus buds off with its envelope 5. Release • Assembled viruses leave their host in one of two ways: • Nonenveloped and complex viruses that reach maturation in the cell nucleus or cytoplasm are released when the cell lyses or rupture • Enveloped viruses are liberated by budding from the membranes of the cytoplasm, nucleus, endoplasmic reticulum, or vesicles • During this process, the nucleocapsid binds to the membrane, which curves completely around it and forms a small pouch • Pinching off the pouch releases the virus with its envelope ©McGraw-Hill Education Lysogenic Cycle Persistent Infections Some cells maintain a carrier relationship: cell harbors the virus and is not immediately lysed: • Can last from a few weeks to the remainder of the host’s life • Can remain latent in the cytoplasm Provirus: • Viral DNA incorporated into the DNA of the host • Measles virus Chronic latent state: • Periodically become activated under the influence of various stimuli • Herpes simplex and herpes zoster viruses ©McGraw-Hill Education Damage to the Host Cell Cytopathic effects (CPEs): virus-induced damage to the cell that alters its microscopic appearance Types of CPEs include: • Gross changes in shape and size • Development of intracellular changes • Inclusion bodies: compacted masses of viruses or damaged cell organelles in the nucleus and cytoplasm • Syncytia: fusion of multiple damaged host cells into single large cells containing multiple nuclei (giant cells) Accumulated damage from a virus infection kills most host cells ©McGraw-Hill Education Cytopathic Changes Jump to long description ©McGraw-Hill Education Source: CDC (a); Courtesy Massimo Battaglia, INeMM CNR, Rome Italy (b) Viruses and Cancer (1) Experts estimate that 13% of cancers are caused by viruses Transformation: the effect of oncogenic, or cancer-causing viruses: • Some viruses carry genes that directly cause cancer • Other viruses produce proteins that induce a loss of growth regulation, leading to cancer ©McGraw-Hill Education Viruses and Cancer (2) Transformed cells: • Increased rate of growth • Changes in their chromosomes • Changes in cell’s surface molecules • Capacity to divide indefinitely Oncoviruses: mammalian viruses capable of initiating tumors: • Papillomaviruses • Herpesviruses • Hepatitis B virus • HTLV-I ©McGraw-Hill Education Viruses That Infect Bacteria Bacteriophage: “bacteria eating”: • Most contain double-stranded DNA, but some RNA types exist as well • Every bacterial species is parasitized by various specific bacteriophages • The bacteria they infect are often more pathogenic for humans ©McGraw-Hill Education T-Even Bacteriophage Infect E. coli Structure: • Icosahedral capsid containing DNA • Central tube surrounded by a sheath • Collar • Base plate • Tail pins • Fibers Jump to long description ©McGraw-Hill Education Events in the Lytic Cycle of T-even Bacteriophages (1) ©McGraw-Hill Education Events in the Lytic Cycle of T-even Bacteriophages (2) ©McGraw-Hill Education Lysogenic Cycle: The Silent Virus Infection Temperate phages: • • Undergo adsorption and penetration Do not undergo replication or release immediately Viral DNA enters an inactive prophage state: • • • Inserted into bacterial chromosome Copied during normal bacterial cell division Lysogeny: a condition in which the host chromosome carries bacteriophage DNA Induction: prophage in a lysogenic cell becomes activated and progresses directly into viral replication and the lytic cycle ©McGraw-Hill Education The Role of Lysogeny in Human Disease Occasionally, phage genes in the bacterial chromosome cause the production of toxins or enzymes that the bacterium would not otherwise have Lysogenic conversion: when a bacterium acquires a new trait from its temperate phage: • Corynebacterium diphtheriae – diphtheria toxin • Vibrio cholerae – cholera toxin • Clostridium botulinum – botulinum toxin ©McGraw-Hill Education Techniques in Cultivating and Identifying Animal Viruses Viruses require living cells as their “medium”: • In vivo: laboratory-bred animals and embryonic bird tissues • In vitro: cell or tissue culture methods Primary purposes of viral cultivation: • Isolate and identify viruses in clinical specimens • Prepare viruses for vaccines • Do detailed research on viral structure, multiplication cycles, genetics, and effects on host cells ©McGraw-Hill Education Using Live Animal Inoculation Specially bred strains of white mice, rats, hamsters, guinea pigs, and rabbits are the usual choices for viral cultivation Occasionally, invertebrates such as insects or nonhuman primates are used Because viruses exhibit host specificity, certain animals can propagate viruses more readily than others ©McGraw-Hill Education Using Bird Embryos Bird eggs containing embryos: • Intact and self-supporting unit • Sterile environment • Contain their own nourishment Chicken, duck, and turkey eggs are the most common choices for inoculation Viruses are injected through the eggshell by drilling a small hole or making a small window ©McGraw-Hill Education Chicken Egg Used to Culture a Virus ©McGraw-Hill Education Using Cell (Tissue) Culture Techniques Isolated animal cells are grown in vitro in cell or tissue culture rather than in an animal or egg Cell culture, or tissue culture: • Grown in sterile chambers with special media that contain the correct nutrients for cells to survive • Cells form a monolayer, or single, confluent sheet of cells that supports viral multiplication • Allows for the close inspection of culture for signs of infection ©McGraw-Hill Education Detection of Viral Growth in Culture Observation of degeneration and lysis of infected cells Plaques: areas where virus-infected cells have been destroyed show up as clear, well-defined patches in the cell sheet: • Visible manifestation of cytopathic effects (CPEs) ©McGraw-Hill Education Normal and Infected Cell Culture Jump to long description ©McGraw-Hill Education Source: Bakonyi T, Lussy H, Weissenböck H, Hornyák A, Nowotny N. Emerging Infectious Diseases, Vol. 11, No. 2, Feb. 2005. Viroids Virus-like agents that parasitize plants About one-tenth the size of an average virus Composed of naked strands of RNA, lacking a capsid or any other type of coating Significant pathogens in economically important plants: tomatoes, potatoes, cucumbers, citrus trees, chrysanthemums ©McGraw-Hill Education Potato Infected With a Virus ©McGraw-Hill Education
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ASC 110 UOS The Potlatch Questions

ASC 110 UOS The Potlatch Questions

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Explanation & Answer:

4 Questions

HNU 560 HU Evidence Based Practice Reflection

HNU 560 HU Evidence Based Practice Reflection

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Reflect back over the term. What one thing did you learn in the course that you were able to apply in your work during the term? What one thing are you most looking forward to applying to your career in the future. What future trends may influence how nurses use evidence to improve the quality of patient care? How will this course content help prepare you for certification in your chosen specialty?

A reminder of the course objectives may help you reflect on this term:

  1. Explain the purpose of nursing research in an evidence-based practice environment.
  2. Differentiate qualitative and quantitative research in terms of philosophy, methodology, and outcome.
  3. Critically analyze various types of research methods, designs, and evidence-based practice for scientific merit.
  4. Investigate the literature to gain knowledge related to a select problem in education, administration or practice.
  5. Evaluate the reliability, validity, and typical outcomes of instruments commonly used for nursing research.
  6. Explore ethical principles as they relate to research and evidence-based practice.
  7. Design an evidence-based practice project that incorporates scholarly inquiry applicable to a select problem in nursing practice, administration, or education.

 

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1 Reflection

PSY 201 BHSU Think Critically Reflect Consciously Essay

PSY 201 BHSU Think Critically Reflect Consciously Essay

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1 Essay

SU Quantum Computing Applications in Solving Scientific Problems Essay

SU Quantum Computing Applications in Solving Scientific Problems Essay

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Research Task 1: Quantum Computing Application

What are the potential applications of quantum computing in solving complex scientific problems?

Instructions: Your task is to conduct a comprehensive literature review and research synthesis on the potential applications of quantum computing in addressing complex scientific problems.  Identify specific scientific domains where quantum computing could make a significant impact and analyze the challenges and opportunities associated with its adoption. The report should include a critical assessment of existing research, recent advancements in quantum algorithms, and potential breakthroughs that may reshape the scientific landscape.

 

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1 Essay

NU 560 HUO Evidence Based Practice Project

NU 560 HUO Evidence Based Practice Project

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Attach your Final Evidence-Based Practice Project PowerPoint (PPT) presentation to this discussion forum.

Include the following in your initial post:

  • Brief description of the practice problem and its significance
  • PICOT Question

How will outcomes be measured?

  • Synthesis of evidence from the three studies selected

 

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1 presentation
1 Paper

UJ COVID 19 Climate Change and Human Security Papers

UJ COVID 19 Climate Change and Human Security Papers

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1. How has the Covid-19 pandemic affected human security?  What lessons do the world?s responses offer humankind as it looks into the future and the various threats it may present? 2. Explain the main impacts of climate change on human, national, and international security. 3. What are the implications of the North-South divide for international security? 4. Explain the human, national and international security implications of illegal immigration, using examples

 

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4 papers